Genes, Development and Cancer (eBook, PDF)

The Life and Work of Edward B. Lewis
Redaktion: Lipshitz, Howard D.

• Format: PDF

Produktbeschreibung

- For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume

- Papers are organized into sections that reflect the focus of the research

- Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 557
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781441989819
• Artikelnr.: 44184077

Inhaltsangabe

Background
Invention of the cis
trans test for position effects
Position pseudoalleles
The bithorax pseudoalleles and the concept of developmental control
Gene evolution by tandem duplication
From cisvection to transvection
Extending the bithorax pseudoallelic series
Genetic versus functional models
From genes to gene complexes
Developmental genetics
Gain
of
function and loss
of
function alleles, and the operon model
Genetic mosaics: spatial and temporal aspects of bithorax function
The 1978 paper: a paradigm for the genetic control of development
Trans
acting regulators: positive and negative control of the homeotic complexes
Cis
regulation within the BX
C: the rules of engagement
Positional cloning of the BX
C
Completing the bithorax mutant series
The molecular basis of developmental control
Bithorax and the evolution of sexually dimorphic traits
DNA sequence motifs in the cis
regulatory regions of the BX
C
Evolution of the HOX complexes
Genetic and somatic effects of ionizing radiation
The political and social context
Leukemia and ionizing radiation
Political fallout
Thyroid radiation doses from weapons fallout
Best estimates of risk: leukemia in populations exposed to low doses of radiation
Estimates of lung cancer risk: the Batelle beagles