Mauro Giacca

Gene Therapy (eBook, PDF)

• Format: PDF

Produktbeschreibung

This book presents to the reader a comprehensive and detailed, yet easily accessible, description of the whole field of gene therapy. It covers topics ranging from vector development to the results of the most recent clinical trials. It includes descriptions of lentiviral and AAV vector development, of therapeutic gene selection (including siRNAs, shRNAs, and microRNAs), and of the most recent clinical applications of gene therapy for diseases of the eye, the cardiovascular system, and the central nervous system. Of note, the book only considers conditions for which transfer of genetic material has already progressed to clinical applications or is close to doing so. The language is plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical fields, whenever technical descriptions are required these are provided. Readers will include graduate students in the life sciences area in their final years of study, PhD students, and medical doctors specializing in different fields of internal and specialist medicine, in addition to research scientists working in various areas of current biomedical research.

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Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 303
• Erscheinungstermin: 1. November 2010
• Englisch
• ISBN-13: 9788847016439
• Artikelnr.: 43995255

Autorenporträt

Mauro Giacca, MD, PhD, is the Director of the Italian Component of the International Centre for Genetic Engineering and Biotechnology (ICGEB), an international research organisation based in Trieste, Italy, and full professor of molecular biology at the Faculty of Medicine of the University of Trieste. Over the last 20 years, he has participated in the front line in the development of the gene therapy field. He is internationally recognized as an expert in AAV vector biology and in the application of AAV vectors for the gene therapy of cardiovascular disorders.

Inhaltsangabe

I. Introduction to gene therapy: 1.1 Historical development. 1.2 Gene therapy: an overview.- II. therapeutic genes: 2.1 Protein coding genes. 2.2 Short non-coding nucleic acids.- III. methods for gene transfer: 3.1 Direct. oculation of DNAs or RNAs. 3.2 Physical methods. 3.3 Chemical methods. 3.4 Viral vectors. IV. gene therapy clinical experimentation: 4.1 Clinical applications of gene therapy: general considerations. 4.2 Gene therapy of haematopoietic stem cells (HSC). 4.3 Gene therapy of cystic fibrosis. 4.4 Gene therapy of muscular dystrophies. 4.5 Gene therapy of haemophilia. 4.6 Gene therapy of cancer. 4.7 Gene therapy of neurodegenerative disorders. 4.8 Gene therapy of eye diseases. 4.9 Gene therapy of cardiovascular disorders. 4.10 Gene therapy of HIV/AIDS. 4.11 Gene therapy of liver diseases. 4.12 Gene therapy of skin diseases. 4.13 Gene therapy of osteoarticular diseases. 4.14 Immune response to gene therapy.- V. social and ethical problems of gene therapy: 5.1 Ethical and social problems of gene therapy.- abbreviations.- glossary.- index.