G Protein Coupled Receptors (eBook, ePUB)

Structure

• Format: ePub

Produktbeschreibung

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.

• Continues the legacy of this premier serial with quality chapters authored by leaders in the field
• Covers G protein coupled receptors
• Contains chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 440
• Erscheinungstermin: 17. Januar 2013
• Englisch
• ISBN-13: 9780123918727
• Artikelnr.: 38016403

Inhaltsangabe

1. G Protein Coupled Receptors: Techniques for Probing Structure
2. Comformational Ensemble View of G Protein-Coupled Receptors and The Effect of Mutations and Ligand Binding
3. Structural Evolution of G-Protein-Coupled Receptors: A Sequence Space Approach
4. Directed Evolution of G Protein-Coupled Receptors for High Functional Expression and Detergent Stability
5. The Role of Hydrophobic Amino Acids in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors
6. Structure of ß-Adrenergic Receptors
7. Advances in Methods to Characterize Ligand-Induced Ionic Lock and Rotamer Toggle Molecular Switch in G-Protein Coupled Receptors
8. Crystallogenesis of Adenosine A_2A Receptor - T4 Lysozyme Fusion Protein: A Practical Route for the Structure
9. Probing GPCR Structure: Adenosine and P2Y Nucleotide Receptors
10. Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs
11. Expression of Mammalian G Protein-Coupled Receptors in Caenorhabditis Elegans
12. Expression, Purification and Structural Analysis of Intracellular C-Termini from Metabotropic Glutamate Receptors
13. Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling
14. Mapping a Ligand Binding Site Using Genetically-Encoded Photoactivatable Crosslinkers
15. Alternative mRNA Splicing of G Protein-Coulped Receptors
16. Functional Residues of the CB1 Cannabinoid Receptor