Fundamentals of Drug Delivery (eBook, ePUB)

Redaktion: Benson, Heather A. E.; Liang, Xiaowen; Williams, Adrian C.; Roberts, Michael S.

• Format: ePub

Produktbeschreibung

A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: * Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics * Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition * Details the physiology and barriers to drug delivery for each administration route * Presents a historical perspective and a look into the possible future of advanced drug delivery systems * Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues * Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 576
• Erscheinungstermin: 30. September 2021
• Englisch
• ISBN-13: 9781119769675
• Artikelnr.: 62736932

Autorenporträt

Heather A.E. Benson, PhD is an Associate Professor at the Curtin Medical School, Curtin University, Australia, where she leads the Skin Delivery Research Group. Michael S. Roberts, PhD is Professor of Therapeutics and Pharmaceutical Science at the University of South Australia, and a Professor of Clinical Pharmacology and Therapeutics at the University of Queensland, Australia. Adrian C. Williams, PhD is Professor of Pharmaceutics and Research Dean at University of Reading, England, UK. Xiaowen Liang, PhD is the UQ Development Fellow at The University of Queensland, Australia.

Inhaltsangabe

Preface xvii

List of Contributors xix

Part I Product Design, the Essence of Effective Therapeutics 1

1 Challenges and Innovations of Controlled Drug Delivery 3
Heather A.E. Benson and Michael S. Roberts

1.1 Background 3

1.2 Parenteral Dosage Forms 3

1.2.1 Intravenous Route (IV) 4

1.2.2 Intramuscular Route (IM) 5

1.2.3 Subcutaneous Route (SC) 5

1.2.4 Other Parenteral Routes 5

1.3 Oral Route and Delivery Systems 6

1.4 Nasal Drug Delivery 6

1.5 Pulmonary Drug Delivery 7

1.6 Transdermal Drug Delivery 7

1.7 Ocular Drug Delivery 9

1.8 Drug Delivery System Development Process 11

1.9 Conclusion 12

References 12

2 Challenges in Design of Drug Delivery Systems 15
S. Narasimha Murthy, Shivakumar H.N, and Sarasija Suresh

2.1 Drug Properties to be Considered in Design of Controlled Release Products 19

2.2 Physicochemical Factors that Need to be Considered in Design of CRDDS 19

2.2.1 Dose Size 19

2.2.2 MolecularWeight/Size 19

2.2.3 Aqueous Solubility 21

2.2.4 Lipid Solubility and Partition Coefficient 25

2.2.5 Physicochemical Stability 26

2.3 Biopharmaceutical Properties that Deserve Consideration in Design of Controlled Release Products 26

2.3.1 Biological Half-life 26

2.3.2 Absorption 27

2.3.3 Metabolism 30

2.3.4 Presystemic Clearance 32

2.3.5 Margin of Safety 32

2.3.6 Adverse Effects 33

2.3.7 Therapeutic Need 33

2.3.8 Role of Circadian Rhythm 34

2.4 Conclusion 35

References 35

3 Drug Delivery of the Future (?) 39
Adrian Williams

3.1 Introduction 39

3.2 Therapeutic Indicators 40

3.3 Drugs of the Future 43

3.4 Delivering the Drugs of the Future 45

3.5 A View to the Longer Term? 47

3.6 Conclusion 50

References 50

4 The Pharmaceutical Drug Development Process: Selecting a Suitable Drug Candidate 37
Lionel Trottet

4.1 The Oral Drug Candidate: How to Get There and Questions to Answer 53

4.2 Challenges for Selecting a Topical Drug Candidate 55

4.3 Percutaneous Flux as a Surrogate Measurement of Skin Tissue Concentration 57

4.4 Learnings from Past Topical Drug Development of Factors Affecting Efficacy 58

4.5 Dermal Pharmacokinetics/Pharmacodynamics 62

4.6 Assessment of Systemic Exposure 63

4.7 Screening Cascade Approach to Select a Dermal Drug Candidate 64

4.7.1 Efficacy (Lack of Target Engagement) 64

4.7.2 Developability 65

4.7.3 Local Safety 65

4.7.4 Systemic Safety 65

4.8 Opportunities for Repurposing Molecules into Dermally Active Treatments for Cosmeceutical or Pharmaceutical Approaches 66

4.9 Conclusion 66

References 67

5 Preformulation and Physicochemical Characterization Underpinning the Development of Controlled Drug Delivery Systems 73
Ronak Savla and Julien Meissonnier

5.1 When Is a Controlled Drug Delivery System Needed? 73

5.2 Optimizing Drug Characteristics 74

5.3 Defining the Product Profile 75

5.4 Preformulation and Physicochemical Characterization Underpinning Development of CDD 77

5.4.1 Feasibility and Risk Assessment 78

5.4.2 Solubility and Dissolution Rate 79

5.4.3 Permeability 82

5.4.4 Drug and Drug Product Particle Sizes 83

5.4.5 Solid-State Chemistry 84

5.4.6 Stability 85

5.4.7 Excipient Compatibility 8