From DNA Photolesions to Mutations, Skin Cancer and Cell Death (eBook, PDF)

Redaktion: Sage, Evelyne; Rouabhia, Mahmoud; Drouin, Regen

• Format: PDF

Produktbeschreibung

As modern day society takes an increasing interest in outdoor activities, its exposure to sunlight has never been greater. As a consequence, countries throughout the world are experiencing a dramatic increase in the incidences of skin carcinomas and melanomas. From DNA photolesions to mutations, skin cancer and cell death provides an authoritative source of information for photobiologists interested in the series of genetic events that occur in the skin, and eventually lead to cancer. With contributions from eminent scientists in the field, this book includes the latest information on DNA photolesions and repair, as well as the key mechanisms of solar UV in skin cancer initiation and development. Significant information relating to UV-induced photolesions and mechanisms of skin tumour occurrence is also included. By providing the basic phenomena underlying the science and an overview of the biological events that take place when cells are exposed to solar UV radiation, From DNA photolesions to mutations, skin cancer and cell death is suitable to all researchers interested in the process of photocarcinogenesis.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 334
• Erscheinungstermin: 31. Oktober 2007
• Englisch
• ISBN-13: 9781847552501
• Artikelnr.: 44761851

Inhaltsangabe

Chapter 1: UVB and UVA Induced Formation of Photoproducts within Cellular
DNA; Chapter 2: Chemical Sequencing Profiles of Photosensitized DNA Damage;
Chapter 3: DNA damage induced by UVA radiation: role in solar mutagenesis;
Chapter 4: Mutations induced by UV and sunlight; Chapter 5: Mechanisms and
Mutagenic Consequences of Photoproduct Bypass by Replicative and DNA Damage
Bypass Polymerases; Chapter 6: The Ogg1 Protein of Saccharomyces
cerevisiae: Properties and Biological Functions; Chapter 7: The role of a
yeast homologue of the human phosphatase activator hPTPA in the cellular
response to oxidative DNA damage; Chapter 8: DNA repair in RNA polymerase I
transcribed genes; Chapter 9: Global Genome Nucleotide Excision Repair: Key
Players and Their Functions; Chapter 10: Efficient Repair of UV-Induced DNA
Damage in Terminally Differentiated Human Keratinocytes; Chapter 11:
Reactivation of UV-damaged viruses and reporter genes in mammalian cells;
Chapter 12: Transcription of p53-regulated genes under transcriptional
stress: implications for nucleotide excision repair; Chapter 13: What a
difference a wavelength makes: The role of p53 in nucleotide excision
repair of UV-induced DNA damage; Chapter 14: p53 and p33ING1: Role in
Nucleotide Excision Repair of UV-Damaged DNA; Chapter 15: Nuclear and
Non-Nuclear Signals Leading to UV-induced Apoptosis; Chapter 16: Opposing
roles of UV-induced apoptosis in early skin cancer; Chapter 17: Acquired
activation of signalling pathways in skin tumours from DNA repair-deficient
xeroderma pigmentosum patients; Chapter 18: Chaos Theory and Self-Organized
Criticality Describe the DNA Damage Signal transduction Network;