Evolution after Gene Duplication (eBook, PDF)

Redaktion: Dittmar, Katharina; Liberles, David A.

• Format: PDF

Produktbeschreibung

Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. Key Features: * Explores comparative genomics, genome evolution studies and analysis of multi-gene families such as Hox, globins, olfactory receptors and MHC (immune system) * A complete post-genome treatment of the topic originally covered by Ohno's 1970 classic, this volume extends coverage to include the fate of associated regulatory pathways * Taps the significant increase in multi-gene family data that has resulted from comparative genomics * Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 352
• Erscheinungstermin: 16. März 2011
• Englisch
• ISBN-13: 9780470619896
• Artikelnr.: 38190719

Autorenporträt

Katharina Dittmar de la Cruz holds both a Ph.D. in Molecular Parisitology and Entomology and a doctorate in Veterinary Medicine, both from the University of Leipzig, Germany. An expert in phylogenetics, molecular evolution, and bioinformatics, she has recently turned her attention toward examining the implications of evolutionary forces on drug design. Dr. Dittmar is an Assistant Professor at the SUNY University at Buffalo. David Liberles earned his Ph.D. in Chemistry at the California Institute of Technology working on the biochemsitry of nucleic acids. Subsequently, he has developed significant expertise in bioinformatics, computational biology and functional genomics. His broad experience includes a professorship at the Stockholm Bioinformatics Center and consultancies with Novo Nordisk and other private research and diagnostic companies. Currently he is Vice-Director of the University of Wyoming Bioinformatics Center and Assistant Professor of Molecular Biology.

Inhaltsangabe

Contributors. Preface 1 Understanding Gene Duplication through Biochemistry
and Population Genetics (David A. Leberles, Grigory Kolesov, and Katharina
Dittmar). 2 Functional Divergence of Duplicated Genes (Takashi Makino,
David G. Knowles, and Aoife McLysaght). 3 Duplication Retention After
Small- and Large-Scale Duplications (Steven Maere and Yves Van de Peer). 4
Gene Dosage and Duplication (Fyodor A. Kondrashov). 5 Myths and Realities
of Gene Duplication (Austin L. Hughes and Robert Friedman). 6 Evolution
After and Before Gene Duplication? (Tobias Sikosek and Erich
Bornberg-Bauer). 7 Protein Products of Tandem Gene Duplication: A
Structural View (William R. Taylor and Michael I. Sadowski). 8 Statistical
Methods for Detecting Functional Divergence of Gene Familiies (Xun Gu). 9
Mapping Gene Gains and Losses Among Metazoan Full Genomes Using an
Integrated Phylogenetic Framework (Athanasia C. Tzika, Raphaël Helaers, and
Michel C. Milinkovitch). 10 Reconciling Phylogenetic Trees (Oliver
Eulenstein, Snehalata Huzurbazar, and David A. Liberles). 11 On the Energy
and Material Cost of Gene Duplication (Andreas Wagner). 12 The Fate of a
Duplication in a Network Context (Orkun S. Soyer). 13 Evolutionary and
Functional Aspects of Genetic Redundancy (Ran Kafri and Tzachi Pilpel). 14
A Phylogenomic Approach to the Evolutionary Dynamics of Gene Duplication in
Birds (Gene L. Organ, Matthew D. Rasmussen, Maude W. Baldwin, Manolis
Kellis, and Scott V. Edwards). 15 Gene and Genome Duplications in Plants
(Pamela S. Soltis, J. Gordon Burleigh, Andre S. Chanderbali, Mi-Jeong Yoo,
and Douglas E. Soltis). 16 Whole Genome Duplications and the Radiation of
Vertebrates (Shigehiro Kuraku and Axel Meyer). Index.

Rezensionen

"This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students." (Forbes.com, 27 October 2010)