Jonathan M. W. Slack, Leslie Dale

Essential Developmental Biology (eBook, PDF)

• Format: PDF

Produktbeschreibung

ESSENTIAL DEVELOPMENTAL BIOLOGY Discover the foundations of developmental biology with this up to date and focused resource from two leading experts The newly revised Fourth Edition of Essential Developmental Biology delivers the fundamentals of the developmental biology of animals. Designed as a core text for undergraduate students in their first to fourth years, as well as graduate students in their first year, the book is suited to both biologically based and medically oriented courses. The distinguished authors presume no prior knowledge of development, animal structure, or histology. The new edition incorporates modern single cell transcriptome sequencing and CRISPR/Cas9, as well as other methods for targeted genetic manipulation. The existing material has also been reorganized to provide for easier reading and learning for students. The book avoids discussions of history and experimental priority and emphasizes instead the modern advances in developmental biology. The authors have kept the text short and focused on the areas truly central to developmental biology. Readers will benefit from the inclusion of such topics as: * A thorough discussion of the groundwork of developmental biology, including developmental genetics, cell signaling and commitment, and cell and molecular biology techniques * An exploration of major model organisms, including Xenopus, the zebrafish, the chick, the mouse, the human, Drosophila, and Caenorhabditis elegans * A treatment of organogenesis, including postnatal development, and the development of the nervous system, mesodermal organs, endodermal organs, and imaginal discs in drosophila * A final section on growth, stem cell biology, evolution, and regeneration Perfect for undergraduate students, especially those preparing to enter teaching or graduate studies in developmental biology, Essential Developmental Biology will also earn a place in the libraries of those in the pharmaceutical industry expected to be able to evaluate assays based on developmental systems.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 544
• Erscheinungstermin: 8. November 2021
• Englisch
• ISBN-13: 9781119512820
• Artikelnr.: 62918182

Autorenporträt

Professor Jonathan M.W. Slack is an emeritus professor of the University of Bath, UK, where he was Head of the Department of Biology and Biochemistry; and the University of Minnesota, USA, where he was director of the Stem Cell Institute. He is a member of the European Molecular Biology Organization and a ??Fellow of the Academy of Medical Sciences. He has published numerous research papers on developmental biology as well as five other books, including The Science of Stem Cells (Wiley-Blackwell 2018). Professor Leslie Dale is Professor of Developmental Biology at University College London, UK, where he was Head of Teaching for the Department of Cell and Developmental Biology. He teaches developmental biology to both undergarduate and medical students. For his PhD he studied regeneration in Drosophila imaginal discs and subsequently the development of Xenopus embryos.

Inhaltsangabe

Preface, ix

About the companion website, xi

Section 1: Groundwork, 1

1 The excitement of developmental biology, 3

Where the subject came from, 3

Impact of developmental biology, 4

Future impact, 5

2 How development works, 7

Ultrashort summary, 7

Gametogenesis, 10

Early development, 13

Growth and death, 19

3 Approaches to development: developmental genetics, 25

Developmental mutants, 25

Sex chromosomes, 27

Maternal and zygotic, 27

Genetic pathways, 28

Genetic mosaics, 30

Screening for mutants, 31

Cloning of genes, 32

Gain-and loss-of-function experiments, 32

Transgenesis, 32

Other gain-of- function techniques, 34

Targeted mutagenesis, 34

Other loss-of- function systems, 35

Gene duplication, 36

Limitations of developmental genetics, 37

4 Approaches to development: experimental embryology and its molecular basis, 39

Normal development, 39

Developmental commitment, 42

Criteria for proof, 48

Transcription factors, 48

Transcription factor families, 50

Other controls of gene activity, 51

Signaling systems, 51

Genetic regulatory networks, 57

5 Approaches to development: cell and molecular biology techniques, 61

Microscopy, 61

Optical techniques, 61

Confocal, multi-photon, and light sheet microscopes, 63

Image capture, 63

Anatomical and histological methods, 64

Microinjection, 66

Study of gene expression by molecular biology methods, 67

Study of gene expression by in situ methods, 72

Reporter genes, 75

Cell-labeling methods, 76

6 Cells into tissues, 81

Cells in embryos, 81

Cytoskeleton, 82

Small GTP-binding proteins, 84

Extracellular matrix, 84

Cell movement, 85

Epithelial organization, 86

Morphogenetic processes, 88

Section 2: Major model organisms, 97

7 Major model organisms, 99

The big six, 99

Access and micromanipulation, 101

Genetics and genomes, 101

Relevance and tempo, 102

Other organisms, 102

8 Xenopus, 107

Oogenesis, maturation, and fertilization, 108

Normal development, 109

Fate maps, 114

Experimental methods, 115

Processes of regional specification, 119

9 The zebrafish, 135

Normal development, 135

Fate map, 140

Genetics, 141

Reverse genetic methods, 144

Embryological techniques, 145

Regional specification, 145

Other roles of the zebrafish, 150

10 The chick, 153

Normal development, 154

Fate map, 158

Regional specification of the early embryo, 159

Description of organogenesis in the chick, 164

11 The mouse, 173

Mammalian fertilization, 173

Normal development of the mouse, 177

Fate map, 184

Regional specification in the mouse embryo, 185

Transgenic mice, 190

Embryonic stem cells, 192

Knockouts and knock-ins, 192

Nuclear transplantation and imprinting, 196

X-inactivation, 196

Teratocarcinoma, 198

12 Human early development, 203

Human reproduction, 203

Preimplantation development, 205

Human embryonic stem cells, 207