Drugs (eBook, PDF)

Photochemistry and Photostability
Redaktion: Albini, Angelo; Fasani, E.

• Format: PDF

Produktbeschreibung

Since Pasteur in 1846, scientists have been aware that many drugs are photoreactive, but until recently research in this area had been somewhat limited. However, since the introduction of acutely sensitive analytical methods, the realisation of the need to identify the photochemical properties of a potential drug as early in its development as possible and the increased attention to the phototoxic effect of drugs, more details are becoming available. Drugs: Photochemistry and Photostability presents the basic elements of the science, and serves as an excellent introduction to this emerging field of photochemistry. Detailed experimental conditions for photostability studies are given, along with a discussion of the recently implemented ICH Guidelines for drug photostability. With contributions from international experts in the field and including a comprehensive literature review, this book provides all the up-to-date information needed by researchers in many fields, especially medicinal and pharmaceutical chemistry.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 334
• Erscheinungstermin: 31. Oktober 2007
• Englisch
• ISBN-13: 9781847550712
• Artikelnr.: 44768941

Inhaltsangabe

Photochemistry of Drugs: An Overview and Practical Problems; Medicinal
Photochemistry (An Introduction with Attention to Kinetic Aspects);
Photoreactivity of Selected Antimalarial Compounds in Solution and in the
Solid State; Photochemistry of Diuretic Drugs in Solution; New Results in
the Photoinstability of Antimycotics; Photoreactivity versus Activity of a
Selected Class of Phenothiazines: A Comparative Study; Photoprocesses in
Photosensitising Drugs containing a Benzophenone-like Chromophore;
Photostability of Coumarin; Photostabilities of Several Chemical Compounds
used as Active Ingredients in Sunscreens; An Analytical and Structural
Study of the Photostability of some Leukotriene B4 Antagonists; Molecular
Mechanisms of Photosensitization Induced by Drugs on Biological Systems and
Design of Photoprotective Systems; A Comparison between the Photochemical
and Photosensitising Properties of Different Drugs; Photostability of Drug
Substances and Drug Products: A Validated Reference Method for Implementing
the ICH Photostability Study Guidelines; The Elaboration and Application of
the ICH Guideline on Photostability. A European View; Selecting the Right
Source for Pharmaceutical Photostability Testing; Design and Validation
Characteristics of the Environmental Chambers for Photostability Testing;
Design Limits and Qualification Issues for Room-size Solar Simulators in a
GLP Environment; Actinometry: Concepts and Experiments; trans
-2-Nitrocinnamaldehyde as Chemical Actinometer for the UV-A Range in
Photostability Testing of Pharmaceuticals; Subject Index.