Drug-Drug Interactions (eBook, ePUB)

Redaktion: David Rodrigues, A.

• Format: ePub

Produktbeschreibung

Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 768
• Erscheinungstermin: 3. Januar 2019
• Englisch
• ISBN-13: 9780429524301
• Artikelnr.: 54909834

Autorenporträt

A. DAVID RODRIGUES is Executive Director, Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ, and received his Ph.D. in Biochemistry from the University of Surrey, Guildford, UK. Dr. Rodrigues is a member of the American Association of Pharmaceutical Scientists and is presently serving on the Scientific Affairs Committee of the International Society for the Study of Xenobiotics. He has authored more than 75 peer-reviewed articles and over one dozen book chapters, and sits on the Editorial Board of three journals (Drug Metabolism and Disposition, Drug Metabolism Letters, and Current Drug Metabolism).

Inhaltsangabe

Introducing Pharmacokinetics and Pharmacodynamic Concepts. In Vitro Enzyme
Kinetics Applied to Drug-Metabolizing Enzymes. Human Cytochromes P450 and
Their Role in Metabolism-Based Drug-Drug Interactions.
UDP-Glucuronosyltransferases. Drug-Drug Interactions Involving the Membrane
Transport Process. In Vitro Models for Studying Induction of Cytochrome
P450 Enzymes. In Vitro Approaches for Studying the Inhibition of
Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes
Responsible for the Metabolism of Drugs (Reaction Phenotyping) with
Emphasis on Cytochrome P450. The Role of P-Glycoprotein in Drug
Disposition: Significance to Drug Development. Cytochrome P450 Protein
Modeling and Ligand Docking. The Role of the Gut Mucosa in Metabolically
Based Drug-Drug Interactions. Mechanism-Based Inhibition of Human
Cytochromes P450: In Vitro Kinetics and In Vitro-In Vivo Correlations.
Transporter-mediated Drug Interactions: Molecular Mechanisms and Clinical
Implications. Metabolism & Transport Drug Interaction Database: a web-based
research and analysis tool. In Vivo Probes for Studying Induction and
Inhibition of Cytochrome P450 Enzymes in Humans. Drug-Drug Interactions:
Clinical Perspective. An Integrated Approach to Assessing Drug-Drug
Interactions: A Regulatory Perspective. Drug-Drug Interactions:
Toxicological Perspectives. Drug-Drug Interactions: Marketing Perspectives.