Drug Discovery for Leishmaniasis (eBook, PDF)

Redaktion: Rivas, Luis; Gil, Carmen

• Format: PDF

Produktbeschreibung

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides.

Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania.

Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.

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Produktdetails

• Verlag: Royal Society of Chemistry
• Seitenzahl: 402
• Erscheinungstermin: 26. Oktober 2017
• Englisch
• ISBN-13: 9781788010177
• Artikelnr.: 50101349

Inhaltsangabe

Leishmaniasis, Impact and Therapeutic Needs; Anti-leishmanial Drug
Discovery: Past, Present and Future Perspectives; From Bench to Bedside:
Development and Optimization of Clinical Therapies for Visceral
Leishmaniasis; Drug Assay Methodology in Leishmaniasis: From the Microplate
to Image Analysis; The Pursuit of Novel Anti-leishmanial Agents by
High-throughput Screening (HTS) of Chemical Libraries; Omics and Their
Impact on the Development of Chemotherapy Against Leishmania; In silico
Tools for Target Identification and Drug Molecular Docking in Leishmania;
Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs;
Natural Products as a Source of New Drugs Against Leishmania;
Organometallic Compounds in Chemotherapy Against Leishmania; New Avenues
for Drug Delivery in Leishmania: Using Treatment of Visceral Leishmaniasis
with Amphotericin B as an Exemplar; Addressing the Molecular Biology of
Leishmania for Drug Development; The Physical Matrix of the Plasma Membrane
as a Target: The Charm of Drugs with Low Specificity; Nutrient Transport
and Sensing as Pharmacological Targets for Leishmaniasis; Carbon Metabolism
as a Drug Target in Leishmania; The Redox Metabolism and Oxidative Stress
in Leishmania as a Crossroads for the Lethal Effect of Drugs; DNA
Topoisomerases as Promising Targets for Leishmania Chemotherapy; Molecular
Basis of Drug Resistance in Leishmania; The Macrophage-Parasite Interface
as a Chemotherapeutic Target in Leishmaniasis