Drug Design (eBook, PDF)

Cutting Edge Approaches
Redaktion: Flower, Darren R

• Format: PDF

Produktbeschreibung

Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others. University and pharmaceutical company libraries will also benefit from having a copy on their shelves.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 202
• Erscheinungstermin: 31. Oktober 2007
• Englisch
• ISBN-13: 9781847550705
• Artikelnr.: 44763584

Inhaltsangabe

Introduction
High-Throughput X-Ray Crystallography for Drug Discovery
Bioinformatics in Drug Design: a GPCR case study
Virtual Screening of Virtual Libraries - an Efficient Strategy for Lead Generation
Virtual Techniques for Lead Optimisation
The Impact of Physical Organic Chemistry on the Control of Drug-like Properties
Mutagenesis and Modelling Highlight the Critical Nature of the TM2-loop-TM3 region of biogenic amine GPCRS
Computational Vaccine Design
Subject Index.