U. Boas, J B Christensen, P M H Heegaard

Dendrimers in Medicine and Biotechnology (eBook, PDF)

New Molecular Tools

• Format: PDF

Produktbeschreibung

Dendrimers are a new class of macromolecule increasingly used in the fields of synthetic organic chemistry, biology, medicine and biotechnology. Dendrimers in Medicine and Biotechnology: New Molecular Tools looks at this exciting and rapidly growing area of science. Using an interdisciplinary approach with particular emphasis on biological applications, the book discusses the relationship between the dendrimer molecular motif and its biological properties. A general introduction to the subject of dendrimers, including definitions of terms and symbols, is provided. Subsequent sections discuss topics including dendrimers in biological systems, dendrimers as drug delivery devices, dendrimers in diagnostics and dendrimer drugs. Throughout the book examples from current research are also provided. This book will appeal to a wide range of scientists, including non specialists who require an introduction to dendrimers, as well as those wishing to know more about the application of dendrimers in the field of biology and medicine.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 190
• Erscheinungstermin: 31. Oktober 2007
• Englisch
• ISBN-13: 9781847552679
• Artikelnr.: 44767493

Autorenporträt

Ulrik Boas received his M. Sc. Degree in organic chemistry from the University of Copenhagen in 1996. After a period as a research scientist in the biotech industry he returned to academics and received a Ph. D. degree in organic and macromolecular chemistry in 2002. He is currently working as a research scientist at the Danish Institute of Food and Veterinary Research. His fields of interest are method development in organic synthesis and the use of dendrimers in immunology and protein chemistry. Jørn B. Christensen received his M. Sc. Degree in organic chemistry from the University of Copenhagen in 1987 and received his Ph.D degree in organic and materials chemistry in 1994. He is currently holding a position as associate professor at the University of Copenhagen. His fields of interest are development of methodologies in organic synthesis, materials science and uses of dendrimers in chemistry. He has published around 60 papers. Peter Heegaard received his M.Sc. degree (biochemistry) from the University of Copenhagen in 1985 and a Ph.D. in protein chemistry from the same university in 1992. He has since worked as an immunologist/protein chemist in infection biology projects at the University of Copenhagen and, presently, at the Danish Institute of Food and Veterinary Research. His is currently occupied with prion diagnostics, acute phase responses in various infection models and peptide and dendrimer immunochemistry. He has published around 70 papers.

Inhaltsangabe

Chapter 1: Dendrimers: Design, synthesis and chemical properties
1.1: Introduction
1.2: Terms and nomenclature in dendrimer chemistry
1.3: Dendrimer design
1.4: Dendrimer synthesis
1.5: Physicochemical properties of dendrimers
1.6: Summary
Chapter 2: Properties of dendrimers in biological systems
2.1: Significance of multivalent binding in biological interactions
2.2: Biocompatibility of dendrimers
2.3: Summary
Chapter 3: Dendrimers as drug delivery devices
3.1: Introduction
3.2: Dendrimer hosts
3.3: Covalently bound dendrimer conjugates
3.4: Dendrimers as gene transfer reagents
3.5: Summary
Chapter 4: Dendrimer drugs
4.1: Introduction
4.2: Antiviral dendrimers
4.3: Antibacterial dendrimers
4.4: Dendrimers in antitumor therapy
4.5: Dendrimer in therapy of other diseases
4.6: Dendrimer based vaccines
4.7: Dendrimer interactions with proteins. Solubilisation of protein aggregates
4.7: Summary
Chapter 5: Dendrimers in diagnostics
5.1: Contrast agents based on dendrimers
5.2: Fluorescence enhanced by dendrimers
5.3: Dendrimers in bioassays
5.4: Summary
Chapter 6: Dendrimers as biomimics
6.1: Introduction
6.2: Deddrimers as protein mimics
6.3: Dendrimers as artificial enzymes
6.4: Dendrimers as artificial antigens, antibodies and cell surfaces
6.5: Summary