Cytotoxic Payloads for Antibody-Drug Conjugates (eBook, ePUB)

Redaktion: Thurston, David E; Jackson, Paul J M

• Format: ePub

Produktbeschreibung

Antibody-drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla(TM)), brentuximab vedotin (Adcetris(TM)), inotuzumab ozogamicin (Besponsa(TM)), gemtuzumab ozogamicin (Mylotarg(TM)) and moxetumomab pasudotox-tdfk (Lumoxiti^®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many.

The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity.

Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 480
• Erscheinungstermin: 11. Juli 2019
• Englisch
• ISBN-13: 9781788018456
• Artikelnr.: 57148604

Inhaltsangabe

Introduction to Antibody
Drug Conjugates (ADCs); Design Factors Important for Antibody
Drug Conjugate (ADC) Payloads; Use of Molecular Modelling Techniques in Antibody
Drug Conjugate (ADC) Payload Discovery and Development; Auristatin Payloads for Antibody
Drug Conjugates (ADCs); Maytansinoid Payloads for Antibody
Drug Conjugates (ADCs); Colchicine
, Vinblastine
, Taxol
and Eribulin
based Payloads for Antibody
Drug Conjugates (ADCs); Traditional Cytotoxic Agents as Antibody
Drug Conjugate (ADC) Payloads; Topoisomerase Inhibitors as Antibody
Drug Conjugate (ADC) Payloads; Duocarmycins as Antibody
Drug Conjugate (ADC) Payloads; CXI Dimers as Antibody
Drug Conjugate (ADC) Payloads; Duocarmycin
PBD Dimers as Antibody
Drug Conjugate (ADC) Payloads; Calicheamicins as Antibody
Drug Conjugate (ADC) Payloads; Pro
pyrrolobenzodiazepines and Conjugates as Antibody
Drug Conjugate (ADC) Payloads; Pyrrolobenzodiazepine Dimers as Antibody
Drug Conjugate (ADC) Payloads; Indolinobenzodiazepine Dimers (IGNs) as Antibody
Drug Conjugate (ADC) Payloads; Pyridinobenzodiazepines (PDDs) as Sequence
selective DNA Mono
alkylating Antibody
Drug Conjugate (ADC) Payloads; Splicing Inhibitors as Antibody
Drug Conjugate (ADC) Payloads; Tubulysins as Antibody
Drug Conjugate (ADC) Payloads; Amatoxins as RNA Polymerase II Inhibiting Antibody
Drug Conjugate (ADC) Payloads; Protein Toxins as Antibody
Drug Conjugate (ADC) Payloads; Occupational Health and Safety Considerations for the Handling and Manufacture of Antibody
Drug Conjugate (ADC) Payloads; The Future of Antibody
Drug Conjugate (ADC) Payloads