Brian S. Everitt, Simon Wessely

Clinical Trials in Psychiatry (eBook, PDF)

• Format: PDF

Produktbeschreibung

At last - a new edition of the highly acclaimed book Clinical Trials in Psychiatry This book provides a concise but thorough overview of clinical trials in psychiatry, invaluable to those seeking solutions to numerous problems relating to design, methodology and analysis of such trials. Practical examples and applications are used to ground theory whenever possible. The Second Edition includes new information regarding: * Recent important psychiatric trials * More specific discussion of psychiatry in the USA and the particular problems of trials in the USA, including comments about the FDA (U.S. Food and Drug Administration) * An extended chapter on meta-analysis * Further discussion of sub-group analysis Special features include appendices outlining how to design and report clinical trials, what websites and software programs are appropriate and an extensive reference section. From the reviews of the First Edition: "Everitt & Wessely are to be congratulated on producing an excellent guide to help overcome the snags in clinical trial research. Clearly written and in an engrossing style, the book is likely to become a classic textbook on clinical trials, and not just in psychiatry. The authors' enthusiasm and grasp of clinical trial research make for a gripping and insightful read...it is one of the very best books that has been written on clinical trials." THE BRITISH JOURNAL OF PSYCHIATRY "The experience of both authors in this area gives the book a very pragmatic approach grounded in reality, with theoretical overviews invariably being followed by practical examples and applications... an invaluable companion to anyone involved in, or contemplating undertaking, clinical trials research." PSYCHOLOGICAL MEDICINE

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 248
• Erscheinungstermin: 2. August 2008
• Englisch
• ISBN-13: 9780470723845
• Artikelnr.: 37298865

Autorenporträt

Brian S. Everitt. Professor of Behavioural Statistics, Department of Biostatistics and Computing, Institute of Psychiatry, King's College, London, UK. Simon Wessely. Professor of Epidemiological and Liaison Psychiatry Director, King's Centre for Military Health Research, Institute of Psychiatry, King's College, London, UK; Department of Psychological Medicine, Weston Education Centre, London, UK.

Inhaltsangabe

Preface to the first edition Preface to the second edition 1. Treatments,
good, bad or worthless - and how do we tell? Treatments worthless - and
worse A brief history of treating the mentally ill Summary 2. The
randomized clinical trial Introduction The clinical trial Ethical issues in
clinical trials Informed consent Compliance Summary 3. Design issues in
clinical trials Introduction Clinical trial designs Methods of
randomization Methods of masking treatments The size of a clinical trial
Interim analysis Summary 4. Special problems of trials in psychiatry
Introduction Explanatory versus pragmatic trials Complex interventions
Outcome measures in psychiatry Summary 5. Some statistical issues in the
analysis of psychiatric trials Introduction P-values and confidence
intervals Using baseline data Longitudinal data Missing values and dropouts
in longitudinal data Multiple outcome measures Intention-to-treat Economic
evaluation of trials Number needed to treat 6. Analysing data from a
psychiatric trial: an example Introduction Beating the Blues Analysis of
the post-treatment BDI scores Graphical displays and summary measure
analysis of longitudinal data Random effects models for the BtB data The
dropout problem in the BtB data Summary 7. Systematic reviews and
meta-analysis Introduction Study selection Publication bias The statistics
of meta-analysis Some examples of meta-analysis of psychiatric trials
Summary 8. RCTs in psychiatry: threats, challenges and the future
Introduction Can randomized clinical trials in psychiatry be justified? Are
randomized clinical trials really necessary? Conflicts of interest
Scandals, trials and tribulations The future of psychiatric trials
Defending the clinical trial Summary Appendix A Issues in the management of
clinical trials- 'how to do it' Introduction Clinical trial protocols
Getting the costs right Collecting and managing the data Writing the
patient information sheet Getting informed consent Maintaining recruitment
Useful web sites Appendix B Writing a trial report Introduction Appendix C
Useful software for clinical trials Introduction Data management Design
Analysis Bibliography Index

Rezensionen

"On balance, readers looking for a practical text to introduce them to the key issues will be well-satisfied with Clinical Trials in Psychiatry." ( Journal of Biopharmaceutical Statistics, Volume 19, Issue 1, 2009)