Joseph J. Stephanos, Anthony W. Addison

Chemistry of Metalloproteins (eBook, PDF)

Problems and Solutions in Bioinorganic Chemistry

• Format: PDF

Produktbeschreibung

Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: * Alkali and alkaline earth cations * Metalloenzymes * Copper proteins * Iron proteins * Vitamin B12 * Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 448
• Erscheinungstermin: 22. Juli 2014
• Englisch
• ISBN-13: 9781118801499
• Artikelnr.: 41221320

Autorenporträt

JOSEPH J. STEPHANOS, PHD, is Associate Professor of Bioinorganic, Biophysical, and Inorganic Chemistry at Menofia University. His research examines metalloprotein chemistry, ligand-binding, and coordination chemistry of biologically active compounds. ANTHONY W. ADDISON, PHD, is Professor of Inorganic Chemistry at Drexel University. His research focuses on bioinorganic chemistry; chemistry of dioxygen- and NO-binding metalloproteins; and the design, synthesis, and properties of novel chelating agents and macrocyclic and oligonuclear metal complexes. His numerous research articles and conference presentations have earned over 8,000 citations and a Hirsch Index of 37.

Inhaltsangabe

Preface ix 1 Introduction 1 Proteins: Formation
Structures
and Metalloproteins
4 References
28 2 Alkali and Alkaline Earth Cations 31 References
67 3 Nonredox Metalloenzymes 71 Carboxypeptidases
75 Carbonic Anhydrase
84 Alcohol Dehydrogenase
88 References
91 4 Copper Proteins 95 Introduction
95 Electronic Spectra of Copper Ions
96 ESR Spectra of Copper Ions
105 Copper Proteins
117 Plastocyanin
119 Azurin and Stellacyanin
127 Superoxide Dismutase
131 Hemocyanin
135 Ascorbic Oxidase
139 References
142 5 Iron Proteins 147 Introduction
147 Electronic Spectra of Iron Ions
148 Mössbauer Spectroscopy of Iron Ions
155 ESR Spectra of Iron (III)
161 Iron Bioavailability
166 Siderophores
171 Iron Storage and Transfer Proteins
184 Ferritin
184 Transferrin
187 Dioxygenase Iron Proteins
195 Iron-Sulfur Proteins
207 Rubredoxin
207 Ferredoxins
212 2Fe-2S Ferredoxins
212 4Fe-4S Ferredoxins
221 Aconitase
226 Hydroxylases
229 Hydrogenases
232 Nitrogenases
240 Binuclear Iron Proteins
251 Hemerythrin
253 Ribotide Reductase
Purple Acid Phosphate
and Methane Monooxygenase
260 Hemoproteins: Classification and Behavior of Heme in Absence of Globins
267 Myoglobin and Hemoglobin
275 Myoglobin
275 Hemoglobin
280 Cytochrome C
298 Electron Transfer in Porphyrins and Metalloporphyrins
301 Catalases
311 Peroxidases
315 Cytochrome P-450
322 Electronic Spectra of Hemoproteins
327 ESR Spectra of Hemoproteins
362 References
378 6 Vitamin B12 393 References
405 7 Chlorophyll 407 References
421 Index 423