Kenji Mori

Chemical Synthesis of Hormones, Pheromones and Other Bioregulators (eBook, PDF)

• Format: PDF

Produktbeschreibung

Many small molecules occur naturally as "messenger" chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: * what are biofunctional molecules? * why must biofunctional molecules be synthesized? * how can we synthesize biofunctional molecules? * the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin * the synthesis of insect juvenile hormones and antifeedants * the synthesis of pheromones and the significance of chirality in pheromone science * the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin * the synthesis of marine antifeedants and medicinal candidates * a synthetic examination of incorrectly proposed structures of biomolecules * reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 320
• Erscheinungstermin: 17. Juli 2010
• Englisch
• ISBN-13: 9780470669198
• Artikelnr.: 38188563

Autorenporträt

Professor Kenji Mori has nearly 50 years experience researching and teaching the synthesis of biofunctional small molecules. He has been awarded the Japan Academy Prize (1981), the Silver Medal of the International Society of Chemical Ecology (1996), the American Chemical Society's Ernest Guenther Award in the Chemistry of Natural Products (1999), the Special Prize of the Society of Synthetic Organic Chemistry, Japan (2003), and the Frantisek Sorm Memorial Medal of the Academy of Sciences of the Czech Republic (2003). He is the author of "The Total Synthesis of Natural Products, Vol. 9" (Wiley, 1992), considered by many to be the authoritative volume on pheromone synthesis, and over 750 peer-reviewed research papers.

Inhaltsangabe

Preface Abbreviations 1. Introduction - Biofunctional Molecules and Organic
Synthesis 1.1 What are biofunctional molecules? 1.2 Developmental stages of
studies on biofunctional molecules 1.3 Small amounts of the samples are now
sufficient for the elucidation of the structures of biofunctional molecules
1.4 Why must biofunctional molecules be synthesized? 1.5 How can we
synthesize biofunctional molecules? 1.6 What kinds of knowledge and
techniques are necessary to synthesize biofunctional molecules? References
2. Synthesis of Phytohormones, Phytoalexins and Other Biofunctional
Molecules of Plant Origin 2.1 Phytohormones 2.2 Phytoalexins 2.3 Plant
allelochemicals 2.4 Other bioactive compounds of plant origin References 3.
Synthesis of Insect Bioregulators other than Pheromones 3.1 Insect juvenile
hormones 3.2 Insect antifeedants 3.3 Insect repellents References 4.
Synthesis of Pheromones 4.1 What are pheromones? 4.2 Methods for
enantioselective synthesis 4.3 Why is it meaningful to synthesize
enantiopure pheromones ? 4.4 Chiral pheromones whose single enantiomers
show bioactivity 4.5 Chiral pheromones whose stereochemistry-bioactivity
relationships are diverse and complicated 4.6 Significance of chirality in
pheromone science References 5. Synthesis of Biofunctional Molecules of
Microbial Origin 5.1 Microbial hormones 5.2 Antibiotics 5.3 Other
biofunctional molecules of microorganisms References 6. Synthesis of Marine
Bioregulators, Medicinals and Related Compounds 6.1 Marine natural products
of ecological importance such as antifeedants 6.2 Marine natural products
of medicinal interest 6.3 Glycosphingolipids and sphingolipids of medical
interests References 7. Synthetic Examination of Incorrectly Proposed
Structures of Biomolecules 7.1 Origin of incorrect or obscure structures
7.2 Structure fabrications of historical interest 7.3 Incorrect structures
resulting from inappropriate use of purification or analytical methods 7.4
Inappropriate structural proposal caused by problems in bioassay methods
7.5 Human errors are inevitable in chemistry, too References 8. Conclusion
-- Science as a Human Endeavor 8.1 Small molecules are also beautiful 8.2
Continuous efforts may bring something meaningful 8.3 Can a scientist
eventually have a hope in future? Acknowledgments Index