Paul Lloyd-Williams, Fernando Albericio, Ernest Giralt

Chemical Approaches to the Synthesis of Peptides and Proteins (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications.
This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 304
• Erscheinungstermin: 18. August 2020
• Englisch
• ISBN-13: 9781000151688
• Artikelnr.: 59951553

Autorenporträt

Paul Lloyd-Williams (Universitat de Barcelona, Barcelona, Spain), Fernando Albericio (Parc Cientific de Barcelona, Spain) and Ernest Giralt (Biomedical Research Institute, Barcelona, Spain)

Inhaltsangabe

IntroductionAmino Acids and Peptide and Protein StructureAmino Acid
Activation and CouplingProtection Schemes for Peptide SynthesisThe
Synthesis of PeptidesSolid-Phase Peptide SynthesisThe Solid
SupportProtection SchemesAttachment of the First Amino Acid to the Solid
SupportChain ElongationCleavage of the Peptide from the ResinExamples of
Protein Synthesis by Linear SPPSPeptide Synthesis in SolutionStrategic
ConsiderationsProtection SchemesChain ElongationFinal Removal of Protecting
GroupsSpecial Approaches to the Synthesis of Peptides in SolutionExamples
of Peptide Synthesis in SolutionConvergent Approaches to the Synthesis of
Large Peptides and ProteinsConvergent Solid-Phase Peptide SynthesisThe
Coupling of Protected Peptide Segments in SolutionCoupling of Minimally
Protected Peptides in Aqueous SolutionChemical Ligation of Peptide
SegmentsFormation of Disulfide BridgesPeptides with Disulfide
BridgesProtection of Cysteine in Peptide SynthesisChemical Methods for the
Formation of Disulfide BridgesRegioselective Disulfide Bridge
FormationPeptide LibrariesMultiple Peptide Synthesis in ParallelPeptide
Library TechniquesExamples of Peptide Library SynthesisiEach chapter
contains References