Chemical Analysis of Antibiotic Residues in Food (eBook, ePUB)

Redaktion: Wang, Jian; Kay, Jack F.; MacNeil, James D.

• Format: ePub

Produktbeschreibung

An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in food The presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical properties, pharmacokinetics, metabolism, distribution, food safety regulations, and chemical analysis. In addition, the material presented includes background information valuable for understanding the choice of marker residue and target animal tissue to use for regulatory analysis. This comprehensive reference: * Includes topics on general issues related to screening and confirmatory methods * Presents updated information on food safety regulation based on routine screening and confirmatory methods, especially LC-MS * Provides general guidance for method development, validation, and estimation of measurement uncertainty Chemical Analysis of Antibiotic Residues in Food is written and organized with a balance between practical use and theory to provide laboratories with a solid and reliable reference on antibiotic residue analysis. Thorough coverage elicits the latest scientific findings to assist the ongoing efforts toward refining analytical methods for producing safe foods of animal origin.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 384
• Erscheinungstermin: 29. November 2011
• Englisch
• ISBN-13: 9781118067192
• Artikelnr.: 37484751

Autorenporträt

JIAN WANG is currently a research scientist leading a research and development unit for the Canadian Food Inspection Agency in Calgary, Alberta. His responsibilities include planning and conducting research projects in method development for antibiotic and pesticide residues in foods using advanced mass spectral analysis techniques such as UPLC/Q-TOF and LC/ESI-MS/MS. He has written over thirty publications for various journals and books. He was most recently awarded the CFIA Science Branch Recognition Award for leading method development on melamine investigation in 2007. JAMES D. MacNEIL retired as head of the Centre for Veterinary Drug Residues of the Canadian Food Inspection Agency in 2007. His recent achievements include receiving the Joint FAO/WHO Expert Committee on Food Additives 50th Anniversary commemorative silver medal awarded in 2006 for services to JECFA; the Public Service of Canada Award of Excellence, a career achievement in 2007; and appointment as scientist emeritus by CFIA in 2008. He is the former scientific editor for "Drugs, Cosmetics, and Forensics" of the Journal of AOAC International and the author of numerous publications on veterinary drug residue analysis. He is currently an adjunct professor in the Department of Chemistry, Saint Mary's University, Halifax, Canada. JACK F. KAY works in the UK Department for Environment, Food and Rural Affairs. He helped draft European Commission Decision 2002/657/EC and, in 2008, introduced joint auditing to this and ISO 17025 standards into a major UK laboratory. He has actively participated in the Codex Committee on Residues of Veterinary Drugs in Food for more than ten years and was appointed an expert advisor on honey to the Food and Agriculture Organization of the United Nations in 2008. Since 2005, he has held an Honorary Senior Research Fellowship in the Department of Mathematics and Statistics at the University of Strathclyde, Scotland.

Inhaltsangabe

Preface xv Acknowledgment xvii Editors xix Contributors xxi 1 Antibiotics: Groups and Properties 1 Philip Thomas Reeves 1.1 Introduction
1 1.2 Antibiotic Groups and Properties
3 1.3 Major Groups of Antibiotics
8 1.4 Restricted and Prohibited Uses of Antimicrobial Agents in Food Animals
52 1.5 Conclusions
52 Acknowledgments
53 References
53 2 Pharmacokinetics
Distribution
Bioavailability
and Relationship to Antibiotic Residues 61 Peter Lees and Pierre-Louis Toutain 2.1 Introduction
61 2.2 Principles of Pharmacokinetics
61 2.3 Administration
Distribution
and Metabolism of Drug Classes
67 2.4 Setting Guidelines for Residues by Regulatory Authorities
81 2.5 Definition
Assessment
Characterization
Management
and Communication of Risk
82 2.6 Residue Violations: Their Significance and Prevention
94 2.7 Further Considerations
98 References
104 3 Antibiotic Residues in Food and Drinking Water
and Food Safety Regulations 111 Kevin J. Greenlees
Lynn G. Friedlander
and Alistair Boxall 3.1 Introduction
111 3.2 Residues in Food--Where is the Smoking Gun?
111 3.3 How Allowable Residue Concentrations Are Determined
113 3.4 Indirect Consumer Exposure to Antibiotics in the Natural Environment
117 3.5 Summary
120 References
121 4 Sample Preparation: Extraction and Clean-up 125 Alida A. M. (Linda) Stolker and Martin Danaher 4.1 Introduction
125 4.2 Sample Selection and Pre-treatment
126 4.3 Sample Extraction
127 4.4 Extraction Techniques
128 4.5 Final Remarks and Conclusions
144 References
146 5 Bioanalytical Screening Methods 153 Sara Stead and Jacques Stark 5.1 Introduction
153 5.2 Microbial Inhibition Assays
154 5.3 Rapid Test Kits
164 5.4 Surface Plasmon Resonance (SPR) Biosensor Technology
174 5.5 Enzyme-Linked Immunosorbent Assay (ELISA)
178 5.6 General Considerations Concerning the Performance Criteria for Screening Assays
181 5.7 Overall Conclusions on Bioanalytical Screening Assays
181 Abbreviations
182 References
182 6 Chemical Analysis: Quantitative and Confirmatory Methods 187 Jian Wang and Sherri B. Turnipseed 6.1 Introduction
187 6.2 Single-Class and Multi-class Methods
187 6.3 Chromatographic Separation
195 6.4 Mass Spectrometry
200 Acknowledgment
219 Abbreviations
220 References
220 7 Single-Residue Quantitative and Confirmatory Methods 227 Jonathan A. Tarbin
Ross A. Potter
Alida A. M. (Linda) Stolker
and Bjorn Berendsen 7.1 Introduction
227 7.2 Carbadox and Olaquindox
227 7.3 Ceftiofur and Desfuroylceftiofur
230 7.4 Chloramphenicol
233 7.5 Nitrofurans
236 7.6 Nitroimidazoles and Their Metabolites
239 7.7 Sulfonamides and Their N4-Acetyl Metabolites
241 7.8 Tetracyclines and Their 4-Epimers
244 7.9 Miscellaneous
246 7.10 Summary
252 Abbreviations
253 References
254 8 Method Development and Method Validation 263 Jack F. Kay and James D. MacNeil 8.1 Introduction
263 8.2 Sources of Guidance on Method Validation
263 8.3 The Evolution of Approaches to Method Validation for Veterinary Drug Residues in Foods
266 8.4 Method Performance Characteristics
268 8.5 Components of Method Development
268 8.6 Components of Method Validation
274 8.7 Performance Characteristics Assessed during Method Development and Confirmed during Method Validation for Quantitative Methods
275 8.8 Significant Figures
289 8.9 Final Thoughts
289 References
289 9 Measurement Uncertainty 295 Jian Wang
Andrew Cannavan
Leslie Dickson
and Rick Fedeniuk 9.1 Introduction
295 9.2 General Principles and Approaches
295 9.3 Worked Examples
297 References
325 10 Quality Assurance and Quality Control 327 Andrew Cannavan
Jack F. Kay
and Bruno Le Bizec 10.1 Introduction
327 10.2 Quality Management
329 10.3 Conformity Assessment
331 10.4 Guidelines and Standards
333 10.5 Quality Control in the Laboratory
336 10.6 Conclusion
344 References
344 Index 347