Bioinformatics for Biologists (eBook, PDF)

Redaktion: Pevzner, Pavel

• Format: PDF

Produktbeschreibung

The computational education of biologists is changing to prepare students for facing the complex datasets of today's life science research. In this concise textbook, the authors' fresh pedagogical approaches lead biology students from first principles towards computational thinking. A team of renowned bioinformaticians take innovative routes to introduce computational ideas in the context of real biological problems. Intuitive explanations promote deep understanding, using little mathematical formalism. Self-contained chapters show how computational procedures are developed and applied to central topics in bioinformatics and genomics, such as the genetic basis of disease, genome evolution or the tree of life concept. Using bioinformatic resources requires a basic understanding of what bioinformatics is and what it can do. Rather than just presenting tools, the authors - each a leading scientist - engage the students' problem-solving skills, preparing them to meet the computational challenges of their life science careers.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 15. September 2011
• Englisch
• ISBN-13: 9781139142939
• Artikelnr.: 38278590

Inhaltsangabe

Preface; Acknowledgements; Introduction Pavel Pevzner and Ron Shamir; Part
I. Genomes: 1. Identifying the genetic basis of disease Vineet Bafna; 2.
Pattern identification in a haplotype block Kun-Mao Chao; 3. Genome
reconstruction: a puzzle with a billion pieces Phillip Compeau and Pavel
Pevzner; 4. Dynamic programming: one algorithmic key for many biological
locks Mikhail Gelfand; 5. Measuring evidence: who's your daddy? Christopher
Lee; Part II. Gene Transcription and Regulation: 6. How do replication and
transcription change genomes? Andrei Grigoriev; 7. Modeling regulatory
motifs Sridhar Hannenhalli; 8. How does influenza virus jump from animals
to humans? Haixu Tang; Part III. Evolution: 9. Genome rearrangements
Steffen Heber and Brian Howard; 10. The crisis of the tree of life concept
and the search for order in the phylogenetic forest Eugene Koonin, Pere
Puigbò and Yuri Wolf; 11. Reconstructing the history of large-scale genomic
changes: biological questions and computational challenges Jian Ma; Part
IV. Phylogeny: 12. Figs, wasps, gophers, and lice: a computational
exploration of coevolution Ran Libeskind-Hadas; 13. Big cat phylogenies,
consensus trees, and computational thinking Seung-Jil Sun and Tiffani
Williams; 14. Algorithm design for large-scale phylogeny Tandy Warnow; Part
V. Regulatory Networks: 15. Biological networks uncover evolution, disease,
and gene functions Nataa Prulj; 16. Regulatory network inference Russell
Schwartz; Index.