Jonathan Pevsner

Bioinformatics and Functional Genomics (eBook, PDF)

• Format: PDF

Produktbeschreibung

Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 792
• Erscheinungstermin: 18. Februar 2005
• Englisch
• ISBN-13: 9780471459170
• Artikelnr.: 37301473

Autorenporträt

Jonathan Pevsner received his Ph.D. in Pharmacology and Molecular Sciences at the Johns Hopkins School of Medicine (1989). There, he identified an odorant-binding protein in nasal secretions. He completed postdoctoral training as a Helen Hay Whitney fellow in the Department of Molecular Physiology at the Stanford University Medical Center. At Stanford he identified proteins that function in neurotransmitter release at nerve terminals. In 1995 he joined the faculty in the Department of Neurology at the Kennedy Krieger Institute and the Department of Neuroscience at the Johns Hopkins School of Medicine. He began teaching bioinformatics in 1996, and introduced a ten-week course in 2000. In 2001 the graduate students voted him Teacher of the Year, and in 2003 the Johns Hopkins faculty gave him the Professor's Award for Excellence in Teaching. His lab studies the molecular basis of childhood neurological disorders including autism and Down Syndrome, and develops bioinformatics software.

Inhaltsangabe

Part I Analyzing DNA RNA and Protein Sequences 1 Introduction 3 2 Access to
Sequence Data and Related Information 19 3 Pairwise Sequence Alignment 69 4
Basic Local Alignment Search Tool (BLAST) 121 5 Advanced Database Searching
167 6 Multiple Sequence Alignment 205 7 Molecular Phylogeny and Evolution
245 Part II Genomewide Analysis of DNA RNA and Protein 8 DNA: The
Eukaryotic Chromosome 307 9 Analysis of Next-Generation Sequence Data 377
10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433 11 Gene
Expression: Microarray and RNA-seq Data Analysis 479 12 Protein Analysis
and Proteomics 539 13 Protein Structure 589 14 Functional Genomics 635 Part
III Genome Analysis 15 Genomes Across the Tree of Life 699 16 Completed
Genomes: Viruses 755 17 Completed Genomes: Bacteria and Archaea 797 18
Eukaryotic Genomes: Fungi 847 19 Eukaryotic Genomes: From Parasites to
Primates 887 20 Human Genome 957 21 Human Disease 1011 GLOSSARY 1075
Self-Test Quiz: Solutions 1103 Author Index 1105 Subject Index 1109