Rosaleen Anderson, Paul W. Groundwater, Adam Todd, Alan Worsley

Antibacterial Agents (eBook, PDF)

Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

• Format: PDF

Produktbeschreibung

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated "lab-to-clinic" approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: * agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents * agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim * agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones * agents targeting cell wall synthesis - beta-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 376
• Erscheinungstermin: 30. Mai 2012
• Englisch
• ISBN-13: 9781118325438
• Artikelnr.: 37354610

Autorenporträt

Professor Rosaleen Anderson, Professor of Pharmaceutical Chemistry, Sunderland Pharmacy School, University of Sunderland, UK Professor Paul Groundwater, Professor of Medicinal Chemistry, Faculty of Pharmacy, The University of Sydney, Australia Dr Adam Todd, Senior Lecturer in Pharmacy Practice, Sunderland Pharmacy School, University of Sunderland, UK Dr Alan Worsley, Principal Lecturer in Pharmacy Practice, Sunderland Pharmacy School, University of Sunderland, UK

Inhaltsangabe

Section One - Introduction to Micro-organisms and Antibacterial Chemotherapy
Micro-organisms - Classification; DNA Replication; Metabolic Processes (Folic Acid Synthesis); Protein Synthesis; Bacterial Cell Wall Synthesis; Bacterial Detection and Identification; Other than its mode of action, what factors determine the antibacterial activity of a drug?; The 'Post-Antibiotic Age'? Section Two - Agents Targeting DNA
Quinolone Antibacterial Agents
Rifamycin Antibacterial Agents
& Nitroimidazole Antibacterial Agents Section Three - Agents Targeting Metabolic Processes
Sulfonamide Antibacterial Agents
Trimethoprim Section Four - Agents Targeting Protein Synthesis
Aminoglycoside Antibiotics
Macrolide Antibiotics
Tetracycline Antibiotics
Chloramphenicol
Oxazolidinones Section Five - Agents Targeting Cell Wall Synthesis
²-Lactam Antibiotics
Glycopeptide Antibiotics
Cycloserine
Isonaizid
Daptomycin