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The management of non-ST segment elevation acute coronary syndromes (NSTE-ACS) has rapidly evolved over the last few years and many guidelines have been provided and already updated. This book is based on the latest ESC Guidelines and reports the current knowledge in NSTE-ACS, together with the most recent therapeutic options and the different strategies that can be applied according to the clinical status of patients. International experts address the different aspects of NSTE-ACS and bring useful information to clinicians, interventionalists and surgeons involved in the difficult management…mehr
The management of non-ST segment elevation acute coronary syndromes (NSTE-ACS) has rapidly evolved over the last few years and many guidelines have been provided and already updated. This book is based on the latest ESC Guidelines and reports the current knowledge in NSTE-ACS, together with the most recent therapeutic options and the different strategies that can be applied according to the clinical status of patients. International experts address the different aspects of NSTE-ACS and bring useful information to clinicians, interventionalists and surgeons involved in the difficult management of these patients. The ESC Education Series This book is part of the ESC Education Series. The series is designed to provide medical professionals with the latest information about the understanding, diagnosis and management of cardiovascular diseases. Where available, management recommendations are based on the established European Guidelines, which encompass the best techniques to use with each cardiac disease. Throughout the series, the leading international opinion leaders have been chosen to edit and contribute to the books. The information is presented in a succinct and accessible format with a clinical focus.
Michael Bertrand, Emeritus Professor of Cardiology, Lille Heart Institute, Lille, France Dr Spencer King III, Fuqua Chair of Interventional Cardiolo, Fuqua institute, Atlanta, GA, USA
Inhaltsangabe
List of contributors viii Preface x Section one: Epidemiology Chapter 1 Epidemiology of non-ST-segment elevation acute coronary syndromes 3 David Hasdai and Alexander Battler Section two: Pathophysiology Chapter 2 Pathologic findings in acute coronary syndromes 11 Erling Falk Chapter 3 Vascular biology of acute coronary syndromes 24 Lina Badimon Section three: Clinical aspects of ACS Chapter 4 Clinical aspects of acute coronary syndromes 43 Eugene McFadden Chapter 5 Circulating biomarkers for risk stratification 52 Christopher Heeschen Section four: Investigation in ACS Chapter 6 Coronary angiography angioscopy and intravascular ultrasound in non-ST-segment elevation acute coronary syndromes 65 Eric Van Belle Christophe Bauters François Schiele and Michel E. Bertrand Chapter 7 New coronary imaging in acute coronary syndrome 78 Pim J. de Feyter Evelyne Regar and Nico R.A. Mollet Section five: Special groups of patients Chapter 8 Acute coronary syndromes in specialgroups of patients 97 Piero O. Bonetti Michael J. Zellweger Christoph Kaiser and Matthias E. Pfisterer Section six: Pharmacological treatment Chapter 9 Antiischemic treatment (nitrates beta-blockers calcium antagonists) 109 David McCarty Colum G. Owens and A.A. Jennifer Adgey Chapter 10 Antiplatelet therapies: aspirin thienopyridines and glycoprotein IIb/IIIa receptor inhibitors 116 Jaydeep Sarma and Keith A.A. Fox Chapter 11 Antithrombin drugs: LMWH unfractionated heparin direct thrombin inhibitors 139 Raphaelle Dumaine and Gilles Montalescot Chapter 12 Statin therapy in ACS 152 François Schiele Section seven: Myocardial revascularization Chapter 13 Percutaneous coronary interventions and stenting/CABG in non-ST-segment elevation acute coronary syndromes 165 Nicolas Meneveau and Jean-Pierre Bassand Section eight: Therapeutic strategy Chapter 14 Risk stratification and therapeutic strategy 187 Christian W. Hamm Chapter 15 Indication for revascularization in non-ST-elevation acute coronary syndrome 199 Lars Wallentin Chapter 16 Management of patients with nonamenable lesions for myocardialrevascul arization 211 Victor Legrand Chapter 17 Non-ST-segment elevation coronary syndromes: European Society of Cardiology guidelines 225 Michel E. Bertrand Chapter 18 Non-ST-segment elevation acute coronary syndromes: ACC/AHA guidelines 236 Pierre Théroux Chapter 19 From guidelines to registries 248 Luigi Tavazzi Section nine: Secondary prevention Chapter 20 Secondary prevention after acute episode of patients presenting with nonpersistent ST-segment elevation 261 Michel E. Bertrand Chapter 21 How to detect vulnerable plaque 270 Dirk Boese and Raimund Erbel Chapter 22 Localversus systemic prevention treatment 281 Mario Togni and Bernhard Meier Conclusions 294 Index 295
List of contributors viii Preface x Section one: Epidemiology Chapter 1 Epidemiology of non-ST-segment elevation acute coronary syndromes 3 David Hasdai and Alexander Battler Section two: Pathophysiology Chapter 2 Pathologic findings in acute coronary syndromes 11 Erling Falk Chapter 3 Vascular biology of acute coronary syndromes 24 Lina Badimon Section three: Clinical aspects of ACS Chapter 4 Clinical aspects of acute coronary syndromes 43 Eugene McFadden Chapter 5 Circulating biomarkers for risk stratification 52 Christopher Heeschen Section four: Investigation in ACS Chapter 6 Coronary angiography angioscopy and intravascular ultrasound in non-ST-segment elevation acute coronary syndromes 65 Eric Van Belle Christophe Bauters François Schiele and Michel E. Bertrand Chapter 7 New coronary imaging in acute coronary syndrome 78 Pim J. de Feyter Evelyne Regar and Nico R.A. Mollet Section five: Special groups of patients Chapter 8 Acute coronary syndromes in specialgroups of patients 97 Piero O. Bonetti Michael J. Zellweger Christoph Kaiser and Matthias E. Pfisterer Section six: Pharmacological treatment Chapter 9 Antiischemic treatment (nitrates beta-blockers calcium antagonists) 109 David McCarty Colum G. Owens and A.A. Jennifer Adgey Chapter 10 Antiplatelet therapies: aspirin thienopyridines and glycoprotein IIb/IIIa receptor inhibitors 116 Jaydeep Sarma and Keith A.A. Fox Chapter 11 Antithrombin drugs: LMWH unfractionated heparin direct thrombin inhibitors 139 Raphaelle Dumaine and Gilles Montalescot Chapter 12 Statin therapy in ACS 152 François Schiele Section seven: Myocardial revascularization Chapter 13 Percutaneous coronary interventions and stenting/CABG in non-ST-segment elevation acute coronary syndromes 165 Nicolas Meneveau and Jean-Pierre Bassand Section eight: Therapeutic strategy Chapter 14 Risk stratification and therapeutic strategy 187 Christian W. Hamm Chapter 15 Indication for revascularization in non-ST-elevation acute coronary syndrome 199 Lars Wallentin Chapter 16 Management of patients with nonamenable lesions for myocardialrevascul arization 211 Victor Legrand Chapter 17 Non-ST-segment elevation coronary syndromes: European Society of Cardiology guidelines 225 Michel E. Bertrand Chapter 18 Non-ST-segment elevation acute coronary syndromes: ACC/AHA guidelines 236 Pierre Théroux Chapter 19 From guidelines to registries 248 Luigi Tavazzi Section nine: Secondary prevention Chapter 20 Secondary prevention after acute episode of patients presenting with nonpersistent ST-segment elevation 261 Michel E. Bertrand Chapter 21 How to detect vulnerable plaque 270 Dirk Boese and Raimund Erbel Chapter 22 Localversus systemic prevention treatment 281 Mario Togni and Bernhard Meier Conclusions 294 Index 295
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