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Madhumeha is one of twenty types of Prameha as described in Ayurvedic classics. It is strikingly resembles with Diabetes mellitus of Modern science. It is becoming a great national catastrophe with a current prevalence rate of 2.4% to 11.6% in urban dwellers. It is taking literally the dimension of an epidemic and more dreaded because of its complications in almost every part of the body. Tendency towards sedentary life style and faulty dietary habits leads to Madhumeha. Shankha prakshalana and various Asana are reliable to control the Madhumeha. Spices are also known to exert several beneficial physiological effects including the anti-diabetic influence. this book detail description of Yogic karma (Shankha prakshalana & Asana), Madhumeha. and Diabetes is mentioned with clinical study