Viruses interact with all forms of life and have shaped evolution for 4 billion years. The COVID-19 pandemic highlights the importance of conducting scientific research into viruses to understand the interactions between them and their hosts. Virology is made up of eight chapters, all of which have been written by outstanding female virologists, emphasizing women?s fundamental role in all aspects of science. It summarizes our current knowledge about the biology of viruses in general and analyzes the specific features of several ones of medical, veterinary and agricultural importance. Genome…mehr
Viruses interact with all forms of life and have shaped evolution for 4 billion years. The COVID-19 pandemic highlights the importance of conducting scientific research into viruses to understand the interactions between them and their hosts.
Virology is made up of eight chapters, all of which have been written by outstanding female virologists, emphasizing women?s fundamental role in all aspects of science. It summarizes our current knowledge about the biology of viruses in general and analyzes the specific features of several ones of medical, veterinary and agricultural importance. Genome replication strategies of different virus families are covered, as well as strategies for survival within their hosts by counteraction of the cellular innate antiviral responses. Attention is also given to viral strategies for efficient dissemination in nature, as well as the evolution of a select group of viruses.
María Carla Saleh is Full Professor at Institut Pasteur, where she directs the Viruses and RNAi unit within the department of Virology. She studies the antiviral response in insects and develops new vector control strategies to eliminate mosquito-borne diseases. During her postdoctoral training at the University of California, San Francisco, USA, she discovered that RNA interference was the antiviral immune system of insects. Félix Augusto Rey directs the Structural Virology unit of Institut Pasteur, France, where he studies the entry mechanisms of lipid-enveloped viruses into cells by using structural approaches. Previously, he has been junior group leader at the CNRS and was chair of Institut Pasteur�s Virology department between 2004 and 2012. During his post-doctoral training at Harvard University, USA, he determined the first structure of a flavivirus envelope protein.
Inhaltsangabe
Introduction xi María-Carla SALEH and Félix AUGUSTO REY
Chapter 1 DNA Viruses 1 Lindsey M COSTANTINI and Blossom DAMANIA
1.1 Introduction to DNA viruses 1
1.1.1 What are the most abundant DNA viruses? 2
1.1.2 Human DNA viruses 4
1.2 Taxonomy and structure 6
1.2.1 Small DNA tumor virus, e.g human papillomavirus 7
1.2.2 Large DNA tumor virus, e.g Kaposi's sarcoma-associated herpesvirus 7
1.3 Genomes 8
1.3.1 HPV, a small DNA tumor virus genome 9
1.3.2 KSHV, a large DNA tumor virus genome 10
1.4 Gene expression and regulation 10
1.4.1 Small DNA tumor virus gene expression, the HPV example 12
1.4.2 Large DNA tumor virus gene expression, the KSHV example 13
1.4.3 DNA virus inhibition of cellular gene expression 14
1.5 Infectious cycle 15
1.5.1 Small DNA tumor virus life cycle, the HPV example 16
1.5.2 Large DNA tumor virus life cycle, the KSHV example 18
1.6 Viral-induced cellular survival 20
1.6.1 Small DNA tumor virus enhancement of cell survival, e.g HPV 21
1.6.2 Large DNA tumor virus enhancement of cell survival, e.g KSHV 21
1.7 Disease prevalence and prevention 22
1.7.1 HPV, a small tumor DNA virus and disease associations 22
1.7.2 KSHV, a large DNA tumor virus and disease associations 24
1.8 Conclusion 25
1.9 References 26
Chapter 2 Double-stranded RNA Viruses 33 Michelle M. ARNOLD, Albie VAN DIJK and Susana LÓPE
2.1 Introduction 33
2.2 Rotaviruses 37
2.2.1 Virion structure 37
2.2.2 Genome 38
2.2.3 Virus entry 39
2.2.4 Transcription, replication and genome segment sorting 40
2.2.5 Host cell interactions: protein synthesis 41
2.2.6 Innate immune evasion 42
2.3 Reoviruses 43
2.3.1 The use of reovirus as an anti-cancer agent 43
2.3.2 Virion structure 43
2.3.3 Genome 44
2.3.4 Virus entry 44
2.3.5 Transcription and protein synthesis 45
2.3.6 RNA packaging and virion assembly 46
2.3.7 Innate immune evasion 48
2.4 Orbiviruses 49
2.4.1 Virion structure 51
2.4.2 Genome 51
2.4.3 Replication cycle 51
2.4.4 Virus entry 52
2.4.5 Transcription, (+)ssRNA selection and packaging, replication 52
2.4.6 Innate immune evasion 54
2.5 Concluding remarks and future challenges to understand dsRNA virus biology 55
