Tuning of Aminoglycoside Properties by Synthetic Dirversification
Aminoglycoside Derivatives
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Aminoglycosides are the naturally occurring organic molecules which are used clinically for the treatment of aerobic gram negative bacterial infection because of their rapid anti-bacterial activity, chemical stability and ability to work in combination with the other drugs. However, toxic side-effects, growing bacterial resistance and poor oral bioavailability have narrowed the significance of aminoglycosides. Synthesis of the various derivatives of aminoglycosides could be a versatile strategy to challenge these limitations. This book summarizes a variety of synthetic strategies utilized to d...
Aminoglycosides are the naturally occurring organic molecules which are used clinically for the treatment of aerobic gram negative bacterial infection because of their rapid anti-bacterial activity, chemical stability and ability to work in combination with the other drugs. However, toxic side-effects, growing bacterial resistance and poor oral bioavailability have narrowed the significance of aminoglycosides. Synthesis of the various derivatives of aminoglycosides could be a versatile strategy to challenge these limitations. This book summarizes a variety of synthetic strategies utilized to diversify the natural aminoglycosides in an attempt to improve the overall characteristics of aminoglycosides.
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