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Coumarin acts as a versatile framework in organic synthesis and drug development due to exhibit useful and diverse biological activities. We summarizes recent instances of coumarin derivative. As interest in the synthesis of coumarins fused or linked with different heterocycle derivatives has been ahead importance over past eras, reflecting the importance of such compounds in both medical and chemical research. Emphasis is placed on the search for innovative coumarin synthesis techniques and the diverse array of biological activities of coumarins. It is believed that the information compiled in this article will update scientists with recent findings of the synthesis and biological activities of coumarin derivatives and inspire them to use this promising moiety for further backbone derivatization and screening, as several novel compounds with biological and chemical properties are possible. Future goals for this field of research include the discovery, synthesis and development of compounds which display increased potency, as well as fuelling structure activity relationship studies aimed at understanding the modes of action of the most biologically active compounds.