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One of the major problems of obstetrics is pregnancy failure, the incidence of which is 10-25%, remaining high to this day. According to several authors, about 55-62% of the multiple causes of miscarriage are coagulation protein or platelet defects, one manifestation of which is antiphospholipid syndrome (APS). To improve the efficiency of measures for early diagnosis, treatment and prevention of AFS complications, a wide range of research work is carried out in the world. In connection with this, the use of anticoagulants for prevention and reduction of recurrent thrombotic complications in women of childbearing age who have obstetric complications is substantiated, improvement of optimal schemes of screening measures, selection of optimal tactics of screening approach, development of risk prevention system for development of reproductive complications.