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This issue of the Interventional Cardiology Clinics edited by Jason Rogers covers various approaches, techniques, and therapies for Transcatheter Mitral Value Intervention. Topics include, but are not limited to: Echocardiographic Imaging of the Mitral Valve for Transcatheter Interventions, Use of Computed Tomography to Guide Mitral Interventions, Transseptal Puncture for Mitral Interventions, MitraClip Therapy for Mitral Regurgitation: Primary MR, Coronary Sinus-Based Approach to Mitral Regurgitation, and Transcatheter Mitral Valve Replacement.