Saleem Shaikh, Zuber Naqvi, Zameer Pasha

Tracing Disease Genes in Non-syndromic Clefts of Orofacial region

TGF - beta 3 and HLA

• Broschiertes Buch

Produktbeschreibung

Orofacial clefts are major human birth defects with complex etiology. Previous studies have proposed Transforming growth factor - beta 3 (TGF-B3) gene as one of the important genes in which polymorphisms may contribute to nonsyndromic cleft lip and palate, however none of the studies included Indian population. The HLA [Human leucocyte antigen] loci are the most polymorphic human proteins, and by virtue of their extreme polymorphism ensure that few individuals are identical. Hence HLA typing can be used to identify a subset of population who are at an increased risk of developing or inheriting a particular disease or anomaly. Studies pertaining to the relationship of HLA haplotype and cleft lip and palate are very few and none of these includes Indian patients. This study is a pioneering step towards establishing an association of HLA class I genes and TGFB3 gene with cleft lip and palate in patients of Indian origin.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 68
• Erscheinungstermin: 31. März 2015
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 119g
• ISBN-13: 9783659688621
• ISBN-10: 3659688622
• Artikelnr.: 42576377

Autorenporträt

The author has more than eight years of teaching experience and is currently working as faculty in college of Dentistry - Majmaah University; Kingdom of Saudi arabia. He has also published many research papers in peer reviewed journals and has presented papers in international and national conferences.