Xiao-Yu Sun

Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B

• Gebundenes Buch

Produktbeschreibung

In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.

Produktdetails

• Springer Theses
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 86023750, 978-3-642-27194-6
• 2012
• Seitenzahl: 236
• Erscheinungstermin: 16. Januar 2012
• Englisch
• Abmessung: 241mm x 160mm x 18mm
• Gewicht: 488g
• ISBN-13: 9783642271946
• ISBN-10: 3642271944
• Artikelnr.: 34513192

Inhaltsangabe

Introduction.- Results and Discussion.- Conclusion.- Experimental Section.- References.- Appendix I.- Appendix II.