R. John Mayer / Aaron J. Ciechanover / Martin Rechsteiner (Hgg.)

The Ubiquitin-Proteasome System

Ed. by John Mayer, Aaron J. Ciechanover and Martin Rechsteiner

• Gebundenes Buch

Produktbeschreibung

The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway.
Drawing on the combined knowledge of the world s leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation.
Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Produktdetails

• Protein Degradation Vol.2
• Verlag: Wiley-VCH
• 1. Auflage
• Seitenzahl: 286
• Englisch
• Abmessung: 243mm x 184mm x 20mm
• Gewicht: 700g
• ISBN-13: 9783527311309
• ISBN-10: 3527311300
• Artikelnr.: 13172874

Autorenporträt

John Mayer obtained his MS and PhD degrees from the University of Birmingham (UK). He is currently serving as Professor of Biochemistry at the School of Biomedical Sciences at Nottingham University.
For the past 30 years, he has investigated intracellular proteolysis and particularly the ubiquitin/proteasome system. Presently, he is particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses.

Aaron Ciechanover obtained his MD from the Hebrew University in Jerusalem (Israel), and his PhD from the Technion-Israel Institute of Technology in Haifa, where he is presently serving as Professor of Biochemistry. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system.

Martin Rechsteiner is Professor of Biochemistry at the University of Utah in Salt Lake City (USA). He is interested in the proteasome component of the ubiquitin-proteasome pathway. He has identified several key regulators of proteasome function and is currently working on their structural and functional elucidation.

Inhaltsangabe

Degrons: signals and sites for ubiquitylation

The proteasome portal and regulation of proteolysis

PAN and the proteasome

Ubiquitin domain proteins

MEKK1: dual function as a protein kinase and a ubiquitin protein ligase

HECT domain ubiquitin protein ligases

UCRP: ubiquitin cross-reactive protein

SUMOs and their function in the cell

Functions of the ubiquitin-proteasome pathway

Molecular Chaperones and the ubiquitin/proteasome system

Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes

Electron microscopy of compartmentalised proteases

Molecular dissection of autophagy in yeast

Rezensionen

"... a comprehensive chapter on the structure of large, self-compartmentalizing proteases ... gives an overview how complex these 'molecular machines' are that keep our cells clean. The individual chapters are followed by extensive references, and this will quarantee immediate guided access to the important literature. In summary, the book provides much more than anyone could assemble from Pubmed in a meaningful way to get informed appropriately." - Zellbiologie aktuell

"...dieses Buch steckt erneut voller brisanter Informationen über eines der zentralsten Themen des Zellgeschehens. Auch im zweiten Band werden wieder die alllerneusten Forschungsergebnisse präsentiert."
Laborjournal

"...liefert wie auch der erste Band höchst brisante Informationen zu einem der wichtigsten Themen des Zellgeschehens, wobei auch hier immer die aktuellsten Forschungsergebnisse präsentiert werden ... für jeden, der sich mit zellulären Regulationsprozessen beschäftigt, unbedingt zu empfehlen..."
Pharmazie in unserer Zeit

"Die Artikel sind kompakt und trotzdem tiefgreifend. Einen visuellen Zugang zum Verständnis bieten hochwertige, meistenteils farbige Bilder. Das Buch ist für jeden geeignet, der sich einen Up-to-date-Überblick über das gesamte Wissensfeld verschaffen oder sich schnell in ein bestimmtes Einzelthema einlesen will, sei er Student oder erfahrener Lebenswissenschaftler. Einen Einstieg zur Vertiefung bietet die sorgfältige Auswahl der Literatur am Ende jedes Kapitels."
Nachrichten aus der Chemie