The Trafficking of the Mycobacterium Tuberculosis PE and PPE Proteins
Phetole Walter Mahasha
Broschiertes Buch

The Trafficking of the Mycobacterium Tuberculosis PE and PPE Proteins

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The expansion of the Mycobacterium tuberculosis PE and PPE gene families seems to be linked to that of the immunologically-important ESAT-6 (esx) gene clusters secretion system, as the ancestral members of these families are found only within the ESAT-6 gene cluster regions. These ancestral members are also the only copies in the earlier mycobacteria like M. smegmatis. The later duplications of the PE and PPE families belonging to the PGRS and MPTR subgroups, have been implicated in virulence and are only found within the genomes of the pathogenic mycobacteria closely related to the M. tubercu...