This handbook explores the biological basis of drug and alcohol use, considering a wide scope of topics from the scientific determination of substance misuse, pharmacokinetics and pharmacodynamics, mechanisms of intoxication, overdose and death; as well as new approaches and controversies such as new types of addictions, decriminalisation, cultural influences and new information on neurobiology.
This handbook explores the biological basis of drug and alcohol use, considering a wide scope of topics from the scientific determination of substance misuse, pharmacokinetics and pharmacodynamics, mechanisms of intoxication, overdose and death; as well as new approaches and controversies such as new types of addictions, decriminalisation, cultural influences and new information on neurobiology.
Part I: Determination of Substance Misuse 1. Genetics and genomics in addiction research - Rohit Jaibhagwan Lodhi, David Rossolatos and Katherine Jean Aitchison 2. Basic Pharmacokinetics of Substance Misuse - Kim Wolff 3. Future Directions: The role of pharmacogenomics - Jason White & Andrew A. Somogyi Part II: PK and PD in Relation to Patterns of Use 4. Alcohol: Pharmacokinetics and Pharmacodynamics - Matthew Goldin and E. Jane Marshall 5. Nicotine: The Pharmacokinetics of Nicotine and Cotinine - Noorzurani Robson 6. Opioids: A Discussion of Pharmacokinetics and Pharmacodynamics in Those Who Misuse Drugs - Verena Metz & Sandy Corner 7. Cocaine: pharmacokinetics, pharmacodynamics and addictive potential - Glenn Dumont 8. Amphetamine & Methamphetamine: Pharmacokinetics and Pharmacodynamics - Kim P.C. Kuypers, Eef Theunissen and Jan Ramaekers 9. MDMA: Pharmacokinetics - Magí Farré, Esther Papaseit & Rafael de la Torre 10. Benzodiazepines: A discussion of pharmacokinetic and pharmacodynamic effects in those who misuse the drug - Alyson Bond & Malcolm Lader 11. Ketamine: the pharmacokinetics and pharmacodynamics in medicinal and misusing populations - Kim Wolff 12. Cannabis: The pharmacokinetics and pharmacodynamics of recreational and medicinal cannabis - Dave Allsop, Richard Kevin & Jonathon Arnold 13. Synthetic cannabinoids: The pharmacokinetics and pharmacodynamics of 'Spice' and other synthetic cannabinoids - Deepak D¿Souza & Aarti Gupta 14. Khat, Methedrone and MDPV: A discussion of pharmacokinetic and pharmacodynamic parameters - Lorenza Colzato & Manuel Ruiz 15. Gamma-hydroxybutyric Acid (GHB): A discussion of pharmacokinetic and pharmacodynamic effects of GHB including its analogues - John B. Saunders, Jason Connor & Gerald Feeney 16. Polysubstance Use - Jason Connor, John Saunders, Adrian Kelly, Gerald Feeney Part III: Detection and Treatment of Drug and Alcohol Use 17. A brief overview of the detection of drug and alcohol use: the matching of purposes and procedures. - Kim Wolff & Michael Gossop 18. Biomarkers of alcohol misuse - Natalie E Walsham & Roy A Sherwood 19. Treatment of Opioid Dependence - Kim Wolff, Steven Karch, Jason White 20. Wastewater Analysis for the Measurement of Population Level Drug Use: Sewage-Based Epidemiology - Bram Miserez & Alexander van Nujs Part IV: Special Settings 21. Forensic toxicology and death investigation - A Robert Forrest 22. Alcohol-related offences, alcohol use disorders and the workplace - Kim Wolff, Samantha Gross, Noor Zurani-Robson and Jane Marshall 23. Future directions: What is the way forward for toxicology and forensic research? - Steven B Karch Part V: Controversies and New Approaches 24. Intravenous abuse of methylphenidate - Bjarni O. Rafnar and Gudrun Dora Bjarnadottir 25. Non addictive drug use: The way forward - Christian P. Müller 26. Different Approaches to setting limits for drugs and alcohol use when driving - Kim Wolff 27. Where do gambling and internet 'addictions' belong? The status of 'other' addictions - Mark D. Griffiths, Daria J. Kuss, Halley M. Pontes and Joël Billieux 28. Emerging Tobacco Trends from the Arabian Cultures (Waterpipe and Dokha): Global Prevalence, Health Risks and Propensity for Abuse - Annie Crookes 29 Treating Benzodiazepine Dependence - abstinence or maintenance? - Deborah Zador 30. ADHD: pathways into addiction, diagnosis and pharmacotherapy - Pieter-Jan Carpentier, Philip Asherson & Ulrich Muller 31. Exploratory models to explain attention deficit hyperactivity disorder and its association with substance use - Susan Young and Ottilie Sedgwick
Part I: Determination of Substance Misuse 1. Genetics and genomics in addiction research - Rohit Jaibhagwan Lodhi, David Rossolatos and Katherine Jean Aitchison 2. Basic Pharmacokinetics of Substance Misuse - Kim Wolff 3. Future Directions: The role of pharmacogenomics - Jason White & Andrew A. Somogyi Part II: PK and PD in Relation to Patterns of Use 4. Alcohol: Pharmacokinetics and Pharmacodynamics - Matthew Goldin and E. Jane Marshall 5. Nicotine: The Pharmacokinetics of Nicotine and Cotinine - Noorzurani Robson 6. Opioids: A Discussion of Pharmacokinetics and Pharmacodynamics in Those Who Misuse Drugs - Verena Metz & Sandy Corner 7. Cocaine: pharmacokinetics, pharmacodynamics and addictive potential - Glenn Dumont 8. Amphetamine & Methamphetamine: Pharmacokinetics and Pharmacodynamics - Kim P.C. Kuypers, Eef Theunissen and Jan Ramaekers 9. MDMA: Pharmacokinetics - Magí Farré, Esther Papaseit & Rafael de la Torre 10. Benzodiazepines: A discussion of pharmacokinetic and pharmacodynamic effects in those who misuse the drug - Alyson Bond & Malcolm Lader 11. Ketamine: the pharmacokinetics and pharmacodynamics in medicinal and misusing populations - Kim Wolff 12. Cannabis: The pharmacokinetics and pharmacodynamics of recreational and medicinal cannabis - Dave Allsop, Richard Kevin & Jonathon Arnold 13. Synthetic cannabinoids: The pharmacokinetics and pharmacodynamics of 'Spice' and other synthetic cannabinoids - Deepak D¿Souza & Aarti Gupta 14. Khat, Methedrone and MDPV: A discussion of pharmacokinetic and pharmacodynamic parameters - Lorenza Colzato & Manuel Ruiz 15. Gamma-hydroxybutyric Acid (GHB): A discussion of pharmacokinetic and pharmacodynamic effects of GHB including its analogues - John B. Saunders, Jason Connor & Gerald Feeney 16. Polysubstance Use - Jason Connor, John Saunders, Adrian Kelly, Gerald Feeney Part III: Detection and Treatment of Drug and Alcohol Use 17. A brief overview of the detection of drug and alcohol use: the matching of purposes and procedures. - Kim Wolff & Michael Gossop 18. Biomarkers of alcohol misuse - Natalie E Walsham & Roy A Sherwood 19. Treatment of Opioid Dependence - Kim Wolff, Steven Karch, Jason White 20. Wastewater Analysis for the Measurement of Population Level Drug Use: Sewage-Based Epidemiology - Bram Miserez & Alexander van Nujs Part IV: Special Settings 21. Forensic toxicology and death investigation - A Robert Forrest 22. Alcohol-related offences, alcohol use disorders and the workplace - Kim Wolff, Samantha Gross, Noor Zurani-Robson and Jane Marshall 23. Future directions: What is the way forward for toxicology and forensic research? - Steven B Karch Part V: Controversies and New Approaches 24. Intravenous abuse of methylphenidate - Bjarni O. Rafnar and Gudrun Dora Bjarnadottir 25. Non addictive drug use: The way forward - Christian P. Müller 26. Different Approaches to setting limits for drugs and alcohol use when driving - Kim Wolff 27. Where do gambling and internet 'addictions' belong? The status of 'other' addictions - Mark D. Griffiths, Daria J. Kuss, Halley M. Pontes and Joël Billieux 28. Emerging Tobacco Trends from the Arabian Cultures (Waterpipe and Dokha): Global Prevalence, Health Risks and Propensity for Abuse - Annie Crookes 29 Treating Benzodiazepine Dependence - abstinence or maintenance? - Deborah Zador 30. ADHD: pathways into addiction, diagnosis and pharmacotherapy - Pieter-Jan Carpentier, Philip Asherson & Ulrich Muller 31. Exploratory models to explain attention deficit hyperactivity disorder and its association with substance use - Susan Young and Ottilie Sedgwick
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