The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease…mehr
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.
The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.
Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
Pascal Dollé, M.D., Ph.D., is Team Leader and Department Head at the Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France Karen Niederreither, Ph.D, is an Associate Professor at the University of Strasbourg, School of Dentistry in Strasbourg, France, and performs research at the IGBMC, Illkirch, France
Inhaltsangabe
Contributors ix Preface xiii Part I: Vitamin A metabolic and enzymatic pathways 1 1 Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms 3 William S. Blaner and Yang Li 2 Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids 35 Earl H. Harrison and Carlo dela Senã's 3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets 57 Joseph L. Napoli and Charles R. Krois 4 Evolution of the Retinoic Acid Signaling Pathway 75 Vincent Laudet, Elisabeth Zieger, and Michael Schubert Part II: Biochemistry and cellular biology of retinoic acid signaling 91 5 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational And Epigenetic Regulatory Mechanisms 93 Marilyn Carrier and Cécile Rochette-Egly 6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes 117 Li-Na Wei 7 Retinoid Receptors: Protein Structure, Dna Recognition and Structure-Function Relationships 131 William Bourguet and Dino Moras 8 How the RAR-RXR Heterodimer Recognizes the Genome 151 Sylvia Urban, Tao Ye, and Irwin Davidson 9 Retinoid Receptor-Selective Modulators: Chemistry, 3D Structures and Systems Biology 165 Marco-Antonio Mendoza-Parra, William Bourguet, Angel R. de Lera, and Hinrich Gronemeyer 10 Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid-Related Molecules are Ligands for the Small Heterodimer Partner (SHP) "Orphan" Receptor 193 Marcia I. Dawson and Zebin Xia 11 The Dual Transcriptional Activity of Retinoic Acid 273 Noa Noy 12 Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice 291 Lorraine J. Gudas Part III: RETINOIC ACID SIGNALING IN DEVELOPMENT 307 13 Retinoic Acid Signaling and Central Nervous System Development 309 Malcolm Maden 14 The Role of Retinoic Acid in Limb Development 339 Gregg Duester 15 Retinoic Acid Signaling and Heart Development 353 Stéphane Zaffran and Karen Niederreither 16 Retinoic Acid in the Developing Lung and Other Foregut Derivatives 371 Wellington V. Cardoso and Felicia Chen 17 Retinoic Acid and the Control of Meiotic Initiation 383 Josephine Bowles and Peter Koopman Part IV: RETINOIDS AND PHYSIOLOGICAL FUNCTIONS 401 18 Retinoids and the Visual Cycle: New Actors for an "OLD" Function 403 Darwin Babino and Johannes von Lintig 19 Retinoid Signaling in the Central Nervous System 421 Peter McCaffery and Wojciech Krezel 20 Retinoid Turnover and Catabolism: Influences of Diet and Inflammation 449 A. Catharine Ross and Reza Zolfaghari 21 Retinoids and the Immune System 465 J. Rodrigo Mora and Makoto Iwata 22 Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation 485 Manuel Mark and Norbert B. Ghyselinck Part V: RETINOIDS, DISEASE AND THERAPY 505 23 Epidemiology and Prevention of Vitamin a Deficiency Disorders 507 Keith P. West, Jr. 24 Retinoid Pathway Gene Mutations and the Pathophysiology Of Related Visual Diseases 529 Yaroslav Tsybovsky and Krzysztof Palczewski 25 Retinoic Acid in Acute Myeloid Leukemias 543 Hugues de Thé and Pierre Fenaux 26 Advances in the Use of Retinoids in Cancer Therapy and Prevention 557 Michael J. Spinella, Sarah J. Freemantle, and Ethan Dmitrovsky Index 575
Contributors ix Preface xiii Part I: Vitamin A metabolic and enzymatic pathways 1 1 Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms 3 William S. Blaner and Yang Li 2 Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids 35 Earl H. Harrison and Carlo dela Senã's 3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets 57 Joseph L. Napoli and Charles R. Krois 4 Evolution of the Retinoic Acid Signaling Pathway 75 Vincent Laudet, Elisabeth Zieger, and Michael Schubert Part II: Biochemistry and cellular biology of retinoic acid signaling 91 5 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational And Epigenetic Regulatory Mechanisms 93 Marilyn Carrier and Cécile Rochette-Egly 6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes 117 Li-Na Wei 7 Retinoid Receptors: Protein Structure, Dna Recognition and Structure-Function Relationships 131 William Bourguet and Dino Moras 8 How the RAR-RXR Heterodimer Recognizes the Genome 151 Sylvia Urban, Tao Ye, and Irwin Davidson 9 Retinoid Receptor-Selective Modulators: Chemistry, 3D Structures and Systems Biology 165 Marco-Antonio Mendoza-Parra, William Bourguet, Angel R. de Lera, and Hinrich Gronemeyer 10 Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid-Related Molecules are Ligands for the Small Heterodimer Partner (SHP) "Orphan" Receptor 193 Marcia I. Dawson and Zebin Xia 11 The Dual Transcriptional Activity of Retinoic Acid 273 Noa Noy 12 Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice 291 Lorraine J. Gudas Part III: RETINOIC ACID SIGNALING IN DEVELOPMENT 307 13 Retinoic Acid Signaling and Central Nervous System Development 309 Malcolm Maden 14 The Role of Retinoic Acid in Limb Development 339 Gregg Duester 15 Retinoic Acid Signaling and Heart Development 353 Stéphane Zaffran and Karen Niederreither 16 Retinoic Acid in the Developing Lung and Other Foregut Derivatives 371 Wellington V. Cardoso and Felicia Chen 17 Retinoic Acid and the Control of Meiotic Initiation 383 Josephine Bowles and Peter Koopman Part IV: RETINOIDS AND PHYSIOLOGICAL FUNCTIONS 401 18 Retinoids and the Visual Cycle: New Actors for an "OLD" Function 403 Darwin Babino and Johannes von Lintig 19 Retinoid Signaling in the Central Nervous System 421 Peter McCaffery and Wojciech Krezel 20 Retinoid Turnover and Catabolism: Influences of Diet and Inflammation 449 A. Catharine Ross and Reza Zolfaghari 21 Retinoids and the Immune System 465 J. Rodrigo Mora and Makoto Iwata 22 Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation 485 Manuel Mark and Norbert B. Ghyselinck Part V: RETINOIDS, DISEASE AND THERAPY 505 23 Epidemiology and Prevention of Vitamin a Deficiency Disorders 507 Keith P. West, Jr. 24 Retinoid Pathway Gene Mutations and the Pathophysiology Of Related Visual Diseases 529 Yaroslav Tsybovsky and Krzysztof Palczewski 25 Retinoic Acid in Acute Myeloid Leukemias 543 Hugues de Thé and Pierre Fenaux 26 Advances in the Use of Retinoids in Cancer Therapy and Prevention 557 Michael J. Spinella, Sarah J. Freemantle, and Ethan Dmitrovsky Index 575
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