The Parvoviridae have been of increasing interest to reseachers in the past decade. Their small size and simple structure have made them ame nable to detailed physiochemical analysis, and from this work relatively detailed information has resulted that has signficantly increased our un derstanding of the biology of these viruses. It has become clear that the Parvoviridae are of interest not only for their own sake, but also because their relative simplicity renders them useful probes in the study of the biology of host cells and of other DNA viruses with which they interact. The Dependovirus…mehr
The Parvoviridae have been of increasing interest to reseachers in the past decade. Their small size and simple structure have made them ame nable to detailed physiochemical analysis, and from this work relatively detailed information has resulted that has signficantly increased our un derstanding of the biology of these viruses. It has become clear that the Parvoviridae are of interest not only for their own sake, but also because their relative simplicity renders them useful probes in the study of the biology of host cells and of other DNA viruses with which they interact. The Dependovirus genus, for instance, contains the defective adeno-as sociated viruses (AA V), which require a coinfection with either an ad enovirus or a herpesvirus for productive multiplication. Studies of AA V, therefore, necessarily impinge on our understanding of the control of macromolecular synthesis by the helper virus. Similarly AA V has been reported to inhibit the oncogenicity of both adeno-and herpesviruses and has been used as a probe of mechanism in these instances as well. Finally, AA V establishes latent infections in vivo and is the only mammalian DNA virus where a comparable model system has been established in cell culture. This system has allowed study of the mechanism of latent infection at the molecular level.
1 Adeno-Associated Virus DNA Structure and Replication.- I. AAV DNA Structure.- II. Replication of AAV.- III. A Model for AAV DNA Replication.- IV. Host and Viral Proteins Required for AAV DNA Replication.- V. Conclusion.- References.- 2 Biology of Adeno-Associated Virus.- I. Introduction.- II. Association with Adenovirus.- III. Host Range.- IV. Experimental Infection in Utero.- V. Latent Infection.- VI. Inhibition of Adenovirus Oncogenicity.- VII. Interactions with Herpesviruses.- References.- 3 Adeno-Associated Virus Defectiveness and the Nature of the Adenovirus Helper Function.- I. Introduction.- II. Biological Background.- III. Definition of the Helper Function.- IV. Genome Structure and Growth Cycle of AAV.- V. Genome Structure and Growth Cycle of Adenovirus.- VI. Role of Specific Adenovirus Genes in AAV Helper Function.- VII. Growth of AAV in Transformed Cells and Inhibition of Adenovirus Functions.- VIII. Summary.- References.- 4 Autonomous Parvovirus DNA Structure and Replication.- I. DNA Structure.- II. DNA Replication.- III. Model for DNA Replication.- References.- 5 Parvovirus Transcription.- I. Introduction.- II. Methods for Study of Transcription.- III. RNA Synthesis and the Virus Growth Cycle.- IV. DNA Genome Orientation and RNA Strand Specificity.- V. In Vivo Transcription. RNA Structure and Genome Location.- VI. In Vitro Synthesis of Parvovirus RNA.- VII. Promoter Structures.- VIII. Post-transcriptional Modification.- IX. Control of RNA Abundance.- X. Coding Potential of Parvovirus mRNA.- XI. Summary.- References.- 6 Variant and Defective Interfering Parvoviruses.- I. Introduction.- II. Nomenclature.- III. Detection of Variant Parvoviruses.- IV. Physical Properties of Variant Particles.- V. Physical Structure of Variant DNA.- VI. In Vitro Construction of Variant Genomes.- VII. In Vivo Generation and Replication of Variants.- VIII. Interfering Properties of Variants.- IX. Mechanism of Interference.- X. Biological Inferences.- References.- 7 Parvovirus Proteins.- I. Introduction.- II. Adenovirus-Associated Virus.- III. Aleutian Disease Virus.- IV. Bovine Parvovirus.- V. Canine Parvovirus.- VI. Densonucleosis Virus.- VII. Feline Panleukopenia Virus.- VIII. H-1 Parvovirus.- IX. LuIII Virus.- X. Minute Virus of Mice.- XI. Porcine Parvovirus.- XII. Rabbit Parvovirus.- XIII. Rat Virus.- XIV. Discussion.- References.- 8 Biology of Pathogenicity of Autonomous Parvoviruses.- I. Introduction.- II. Antigenic Structure and Serologic Relationship.- III. Propagation and Assay Systems.- IV. Pathogenesis.- References.- 9 Canine Parvovirus: Origin and Significance of a "New" Pathogen.- I. Introduction.- II. The Virus.- III. The Disease.- IV. The Origin of CPV.- V. Conclusions.- References.- Addendum The Human Parvovirus.- I. A Ubiquitous Virus Associated with Erythema Infectiosum?.- References.
1 Adeno-Associated Virus DNA Structure and Replication.- I. AAV DNA Structure.- II. Replication of AAV.- III. A Model for AAV DNA Replication.- IV. Host and Viral Proteins Required for AAV DNA Replication.- V. Conclusion.- References.- 2 Biology of Adeno-Associated Virus.- I. Introduction.- II. Association with Adenovirus.- III. Host Range.- IV. Experimental Infection in Utero.- V. Latent Infection.- VI. Inhibition of Adenovirus Oncogenicity.- VII. Interactions with Herpesviruses.- References.- 3 Adeno-Associated Virus Defectiveness and the Nature of the Adenovirus Helper Function.- I. Introduction.- II. Biological Background.- III. Definition of the Helper Function.- IV. Genome Structure and Growth Cycle of AAV.- V. Genome Structure and Growth Cycle of Adenovirus.- VI. Role of Specific Adenovirus Genes in AAV Helper Function.- VII. Growth of AAV in Transformed Cells and Inhibition of Adenovirus Functions.- VIII. Summary.- References.- 4 Autonomous Parvovirus DNA Structure and Replication.- I. DNA Structure.- II. DNA Replication.- III. Model for DNA Replication.- References.- 5 Parvovirus Transcription.- I. Introduction.- II. Methods for Study of Transcription.- III. RNA Synthesis and the Virus Growth Cycle.- IV. DNA Genome Orientation and RNA Strand Specificity.- V. In Vivo Transcription. RNA Structure and Genome Location.- VI. In Vitro Synthesis of Parvovirus RNA.- VII. Promoter Structures.- VIII. Post-transcriptional Modification.- IX. Control of RNA Abundance.- X. Coding Potential of Parvovirus mRNA.- XI. Summary.- References.- 6 Variant and Defective Interfering Parvoviruses.- I. Introduction.- II. Nomenclature.- III. Detection of Variant Parvoviruses.- IV. Physical Properties of Variant Particles.- V. Physical Structure of Variant DNA.- VI. In Vitro Construction of Variant Genomes.- VII. In Vivo Generation and Replication of Variants.- VIII. Interfering Properties of Variants.- IX. Mechanism of Interference.- X. Biological Inferences.- References.- 7 Parvovirus Proteins.- I. Introduction.- II. Adenovirus-Associated Virus.- III. Aleutian Disease Virus.- IV. Bovine Parvovirus.- V. Canine Parvovirus.- VI. Densonucleosis Virus.- VII. Feline Panleukopenia Virus.- VIII. H-1 Parvovirus.- IX. LuIII Virus.- X. Minute Virus of Mice.- XI. Porcine Parvovirus.- XII. Rabbit Parvovirus.- XIII. Rat Virus.- XIV. Discussion.- References.- 8 Biology of Pathogenicity of Autonomous Parvoviruses.- I. Introduction.- II. Antigenic Structure and Serologic Relationship.- III. Propagation and Assay Systems.- IV. Pathogenesis.- References.- 9 Canine Parvovirus: Origin and Significance of a "New" Pathogen.- I. Introduction.- II. The Virus.- III. The Disease.- IV. The Origin of CPV.- V. Conclusions.- References.- Addendum The Human Parvovirus.- I. A Ubiquitous Virus Associated with Erythema Infectiosum?.- References.
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