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This book tells the forgotten story of the pursuit of a Third Way in biology, known by many names, including "the organic philosophy"--including the scientists who defined and refined it and its persistence into the twentieth and twenty-first centuries. It considers the creation of the subfield of epigenetics, a product of Third Way thinking, rooted among a group of scholars known as the Theoretical Biology Club. And it raises significant questions about how we should model the development of the discipline of biology.