The formulation and evaluation of the sustained release matrix tablets

The formulation and evaluation of the sustained release matrix tablets

Phenylpropanolamine Hydrogen Chloride

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The aim of the present research work was to formulate and evaluate the sustained release matrix tablets of Phenylpropanolamine HCl, in order to improve patient compliance and reduce the adverse effect by reducing the dosing frequency. The absence of interaction between the drug and the proposed excipients was confirmed by IR spectroscopy and DSC. The matrix tablets were formulated by wet granulation technique using hydrophilic, hydrophobic, and waxy polymers, alone or in combination. Initial trials indicated that the use of EC and HPMC alone were not helpful in successfully retarding the relea...