Our understanding of cancer has expanded in multiple directions including pathophysiological, biochemical, toxicological, and pharmacological aspects. Collectively, these areas will strengthen the ability to harness the greater benefit of oncology research to improve patient survival and quality of life and this is illustrated in this volume.
Our understanding of cancer has expanded in multiple directions including pathophysiological, biochemical, toxicological, and pharmacological aspects. Collectively, these areas will strengthen the ability to harness the greater benefit of oncology research to improve patient survival and quality of life and this is illustrated in this volume.
Franklyn De Silva - S. F. De Silva is a Ph.D. candidate in Pharmacy/ Pharmaceutical Sciences (completion 2022) enrolled in the College of Graduate and Postdoctoral Studies, and the College of Pharmacy and Nutrition, at the University of Saskatchewan, Canada. He is a member of the Drug Discovery and Development Research Group. Franklyn has an AS in Biotechnology from Ellsworth College, Iowa, USA; a BS (double major: Biotechnology and Chemistry, minor in Biology) and MS (Biology: Cell Biology and Molecular Pharmacology) from West Texas A & M University, USA; and completed a biomedical research internship at Texas Tech University Health Sciences Center, USA. He has worked in the USA and Canada as a biomedical research scientist in areas involving cell & molecular biology, medicinal chemistry, pharmaco-kinetics/dynamics, xenobiotics, nutrient transporters, cellular metabolism, small molecule drugs, natural products, and nutraceuticals. Jane Alcorn - J. Alcorn is Dean and Professor of the College of Pharmacy and Nutrition, University of Saskatchewan. She has a Doctor of Veterinary Medicine from the Western College of Veterinary Medicine, University of Saskatchewan, and a Ph.D. in Pharmaceutical Sciences (Pharmacokinetics) from the University of Kentucky. Jane Alcorn is a member of the Drug Discovery and Development Research Group and the Cannabinoid Research Initiative of Saskatchewan. Jane's expertise in pharmacokinetics has been applied to numerous collaborative research projects involving cancer and the health benefits of phytochemicals such as flaxseed lignans and the cannabinoids.
Inhaltsangabe
Overview and Current Status of Cancer Introduction Incidence, Mortality, and Prevention Diagnosis and Pathobiology Introduction Diagnosis Evolutionary Paradigms and Origin of Cancer Heterogeneity and Dynamics of Cancer Hallmarks of Cancer Molecular Biology of Carcinogenesis Genetic Underpinnings Epigenetic Underpinnings Characteristics, Events, and Stages in Tumorigenesis Introduction Metastases and the Microenvironment Cell-of-Origin, Disseminated and Circulating Tumor Cells, and Cancer Stem Cells Tumor-derived Exosomes and Particles Oncogenic Viruses Metabolic Syndrome and Cancer Metabolism Convoluted Neovascularization Treatments and Challenges Introduction Chemotherapy, Radiotherapy, and Targeted Therapy Immunotherapy Drug Resistance and Cellular Reprogramming Efficient Biomarkers The Role of Nutraceuticals and Natural Products Physiologically Relevant Nutrikinetics and Nutridynamics Additional Remarks, Perspectives, and Conclusions References
Overview and Current Status of Cancer Introduction Incidence, Mortality, and Prevention Diagnosis and Pathobiology Introduction Diagnosis Evolutionary Paradigms and Origin of Cancer Heterogeneity and Dynamics of Cancer Hallmarks of Cancer Molecular Biology of Carcinogenesis Genetic Underpinnings Epigenetic Underpinnings Characteristics, Events, and Stages in Tumorigenesis Introduction Metastases and the Microenvironment Cell-of-Origin, Disseminated and Circulating Tumor Cells, and Cancer Stem Cells Tumor-derived Exosomes and Particles Oncogenic Viruses Metabolic Syndrome and Cancer Metabolism Convoluted Neovascularization Treatments and Challenges Introduction Chemotherapy, Radiotherapy, and Targeted Therapy Immunotherapy Drug Resistance and Cellular Reprogramming Efficient Biomarkers The Role of Nutraceuticals and Natural Products Physiologically Relevant Nutrikinetics and Nutridynamics Additional Remarks, Perspectives, and Conclusions References
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