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This book was designed to investigate interactive simulation in a high school biology class with a focus on whether interactive simulation technology had an effect on academic achievement, as measured by standardized assessment scores. Also, the study included a survey to measure student attitudes and opinions towards this technology and to determine whether there was a link between positive attitudes towards technology and assessment scores. The study was conducted on 68 female students from 11th grade in the city of Riyadh, the Kingdom of Saudi Arabia. Data were obtained through the use of an experimental design, conducted with a control group of 34 students taught through traditional approaches. The experimental group of 34 students was taught using interactive simulation technology. The data were analyzed by assessing both groups of students comparing scores on the standardized unit assessments between the control and experimental group and analyzing the survey data from the experimental group.