Andre S. Merbach, Lothar Helm, Éva Tóth

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

• Gebundenes Buch

Produktbeschreibung

Magnetic Resonance Imaging (MRI) is one of the most importanttools in clinical diagnostics and biomedical research. Thiscompletely revised and extended second edition is presented incolor and includes new chapters on targeted, responsive, PARACESTand nanoparticle MRI contrast agents. It covers the basicchemistries, MR physics and most important techniques used bychemists in the characterization of MRI agents from every angle,from synthesis to safety considerations. Essential readingfor professionals involved in the development and application ofcontrast agents in MRI.

Produktdetails

• Verlag: Wiley & Sons / Wiley-Blackwell
• Artikelnr. des Verlages: 1W119991760
• 2. Aufl.
• Seitenzahl: 512
• Erscheinungstermin: 15. April 2013
• Englisch
• Abmessung: 254mm x 192mm x 32mm
• Gewicht: 1245g
• ISBN-13: 9781119991762
• ISBN-10: 1119991765
• Artikelnr.: 36697971

Autorenporträt

Lothar Helm studied physics at the University of Karlsruhe and got his diploma in 1977 in physical chemistry and electrochemistry. In 1980 he obtained his Ph.D. and joined the Institute of Inorganic Chemistry at the University of Lausanne as post-doc. In 1999 he was appointed Privat Docent at the Faculty of Science of the University of Lausanne. Since 2006 he is titular professor and director of the NMR service of the Institute of Chemical Sciences and Engineering. André E. Merbach, studied at the University of Lausanne and in 1964 was awarded a PhD. He then spent a Postdoctoral Fellowship in the Lawrence Radiation Laboratory at UC Berkeley. In 1965 he returned to the Institute of Inorganic and Analytical Chemistry at Lausanne and created a research and teaching program in coordination chemistry. In 1973, the Swiss Chemical Society awarded him the Werner Prize and Medal for his research and he was nominated Professor of Inorganic and Analytical Chemistry. éva T?th of the Centre de Biophysique Moleculaire, CNRS, Orleans, France, received her Ph.D. in 1994 at the University of Debrecen, Germany and then from 1995-2000 carried out post-doctoral research at the University of Lausanne with Professor Merbach. From 2001-2005 she was based at the EPFL before taking up the position of Director of Research at the CBM in Orleans. She has over 80 journal papers, 4 book chapters as well as acting as co-editor for the 1st edition of this book which was published in 2001.

Inhaltsangabe

List of Contributors xiii Preface xv 1 General Principles of MRI 1 Bich-Thuy Doan, Sandra Meme, and Jean-Claude Beloeil 1.1 Introduction 1 1.2 Theoretical basis of NMR 1 1.3 Principles of magnetic resonance imaging 5 1.4 MRI pulse sequences 11 1.5 Basic image contrast: Tissue characterization without injection of contrast agents (main contrast of an MRI sequence: Proton density (P), T1 and T2, T* 2) 16 1.6 Main contrast agents 18 1.7 Examples of specialized MRI pulse sequences for angiography (MRA) 21 References 23 2 Relaxivity of Gadolinium(III) Complexes: Theory and Mechanism 25 E
va Töth, Lothar Helm, and Andre
Merbach 2.1 Introduction 25 2.2 Inner-sphere proton relaxivity 28 2.3 Second- and outer-sphere relaxation 64 2.4 Relaxivity and NMRD profiles 66 2.5 Design of high relaxivity agents: Summary 75 References 76 3 Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes 83 Jan Kotek, Vojt¢§ech Kub
(c)¥¢§cek, Petr Hermann, and Ivan Luke¢§s 3.1 Introduction - general requirements for the ligands and complexes 83 3.2 Contrast agents employing linear polyamine scaffold 84 3.3 Contrast agents employing cyclen scaffold 103 3.4 Other types of ligands 123 3.5 Bifunctional ligands and their conjugations 134 3.6 Synthesis and characterization of the Ln(III) complexes 138 List of Abbreviations 144 References 146 4 Stability and Toxicity of Contrast Agents 157 Ern~o Br
ucher, Gyula Tircs
o, Zsolt Baranyai, Zolt
an Kov
acs, and A. Dean Sherry 4.1 Introduction 157 4.2 Equilibrium calculations 158 4.3 Stability of metal-ligand complexes 160 4.4 Kinetics of M(L) complex formation 184 4.5 Dissociation of M(L) complexes 186 4.6 Biodistribution and in vivo toxicity of Gd3+-based MRI contrast agents 193 4.7 Concluding remarks 201 Acknowledgements 201 References 201 5 Structure, Dynamics, and Computational Studies of Lanthanide-Based Contrast Agents 209 Joop A. Peters, Kristina Djanashvili, Carlos F.G.C. Geraldes, and Carlos Platas-Iglesias 5.1 Introduction 209 5.2 Computational methods 210 5.3 Lanthanide-induced NMR shifts 213 5.4 Lanthanide-induced relaxation rate enhancements 219 5.5 Anisotropic hyperfine interactions on the first coordination sphere water molecules 221 5.6 Evaluation of geometries by fitting NMR parameters 222 5.7 Two-dimensional NMR 224 5.8 139La and 89Y NMR 224 5.9 Water hydration numbers 225 5.10 Chirality of lanthanide complexes of polyaminocarboxylates 227 5.11 Complexes of non-macrocyclic polyaminocarboxylates 227 5.12 Complexes of macrocyclic ligands 244 5.13 Fullerenes 265 References 267 6 Electronic Spin Relaxation and Outer-Sphere Dynamics of Gadolinium-Based Contrast Agents 277 Pascal H. Fries and Elie Belorizky 6.1 Introduction 277 6.2 Theory of electronic spin relaxation of Gd3+ ions 279 6.3 Outer-sphere dynamics 289 6.4 Relaxivity quenching by the electronic spin relaxation 295 6.5 Various experimental approaches of the electronic spin relaxation 301 6.6 Conclusion and perspectives 306 6.A Appendix: Similar evolutions of the macroscopic magnetization of the electronic spin and of its correlation functions 307 References 308 7 Targeted MRI Contrast Agents 311 Peter Caravan and Zhaoda Zhang 7.1 Introduction 311 7.2 Serum albumin 313 7.3 Fibrin 319 7.4 Type I collagen 325 7.5 Elastin 326 7.6 Sialic acid 327 7.7 alphaVß3 integrin 328 7.8 Folate receptor 329 7.9 Matrix metalloproteinases (MMP) 330 7.10 E-selectin 331 7.11 Fibrin-fibronectin complex 332 7.12 Alanine aminopeptidase (CD13) 332 7.13 Carbonic anhydrase 333 7.14 Interleukin 6 receptor 334 7.15 Estrogen and progesterone receptors 335 7.16 Contrast agents based on natural products 336 7.17 Messenger RNA (mRNA) 337 7.18 Myelin 338 7.19 DNA 338 7.20 Conclusions 340 References 340 8 Responsive Probes 343 Ce
lia S. Bonnet, Lorenzo Tei, Mauro Botta, and E
va Töth 8.1 Introduction 343 8.2 Probes responsive to physiological parameters 344 8.3 Conclusions 381 References 382 9 Paramagnetic CEST MRI Contrast Agents 387 Enzo Terreno, Daniela Delli Castelli, and Silvio Aime 9.1 Introduction 387 9.2 Theoretical and practical considerations on CEST response 388 9.3 Diamagnetic versus paramagnetic CEST agents 400 9.4 Paramagnetic CEST agents 401 9.5 Other exchange-mediated contrast modes accessible for paramagnetic CEST agents 419 9.6 Concluding remarks 421 References 421 10 Superparamagnetic Iron Oxide Nanoparticles for MRI 427 Sophie Laurent, Luce Vander Elst, and Robert N. Muller 10.1 Introduction 427 10.2 Synthesis of iron oxide nanoparticles 428 10.3 Stabilization 431 10.4 Methods of vectorization for molecular imaging 432 10.5 Characterization 436 10.6 Applications 440 10.7 Conclusions 444 Acknowledgements 444 References 444 11 Gd-Containing Nanoparticles as MRI Contrast Agents 449 Klaas Nicolay, Gustav Strijkers, and Holger Gr
ull 11.1 Introduction 449 11.2 Length scales and excretion pathways 452 11.3 Preparation of Gd-containing nanoparticles 454 11.4 Methods for nanoparticle characterization 460 11.5 In vitro applications 468 11.6 In vivo applications 475 11.7 Conclusions and future perspectives 481 Acknowledgements 483 References 483 Index 489