Saber Jedidi

The benefits of sage officinale on hepato-renal toxicity

Antioxidant potential of Salvia officinalis L. against castor oil-induced hepato-renal toxicity

• Broschiertes Buch

Produktbeschreibung

Phenolic compounds are secondary metabolites that are widely used as powerful alternatives to synthetic drugs. The present study was carried out to evaluate the hepato-nephroprotective role of Salvia officinalis aqueous leaf extract (EASO) against castor oil (RH)-induced liver and kidney toxicities in Wistar rats. Results showed that EASO offered significant protection against HR-induced macroscopic liver and kidney alterations. In addition, EASO corrected lipid peroxidation, depletion of enzymatic antioxidants (SOD, CAT and GPx) and non-enzymatic antioxidants (GSH and -SH groups) induced by HR administration. We also demonstrated that EASO protects against castor oil-induced inflammation. In conclusion, our data suggest that EASO at increasing doses exerted a protective effect against all the macroscopic and biochemical disturbances induced by HR intoxication. Thus, sage consumption is strongly recommended as a strategy in the treatment of hepato-renal disorders.

Produktdetails

• Verlag: Our Knowledge Publishing
• Seitenzahl: 64
• Erscheinungstermin: 28. Juli 2023
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 113g
• ISBN-13: 9786206286592
• ISBN-10: 6206286592
• Artikelnr.: 68499083

Autorenporträt

Saber JEDIDIDocteur en sciences biologiques, spécialité : Physiologie animale. Chef du Laboratoire de Ressources Sylvo-Pastorales de Tabarka et chercheur dans le domaine : Valorisation des molécules bioactives naturelles et leurs actions préventives sur les pathologies digestives et les troubles métaboliques associés induits expérimentalement chez les rongeurs.