Heidar-Ali Tajmir-Riahi

The anticancer drug doxorubicin binds DNA and RNA at different locations

• Broschiertes Buch

Produktbeschreibung

In the past 50 years, doxorubicin (DOX) known as adriamycin remains one of the most effective chemotherapeutic anticancer drugs for the treatment of different types of cancers. We compare the binding sites of doxorubicin with DNA and tRNA. DOX binding is via intercalation into DNA duplex, while it binds to tRNA through major and minor grooves. DOX-DNA intercalation is close to A-7, C-5, C-19 (H-bonding with DOX NH2 group), G-6, T-8 and T-18 with the free binding energy of -4.99 kcal/mol. DOX-tRNA bindings are near A-29, A-31, A-38, C-25, C-27, C-28, G-30 (H-bonding) and U-41 with the free binding energy of -4.44 kcal/mol. Drug intercalation induced a partial B to A-DNA transition, while tRNA remained in A-family structure. The structural differences observed between DOX bindings to DNA and tRNA can be the main reasons for drug antitumor activity. The results of in vitro MTT assay on SKC01 colon carcinoma are consistent with the observed DNA structural changes.

Produktdetails

• Verlag: Éditions universitaires européennes
• Seitenzahl: 96
• Erscheinungstermin: 21. Juni 2017
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 161g
• ISBN-13: 9783330877061
• ISBN-10: 3330877065
• Artikelnr.: 48550101

Autorenporträt

H.A. Tajmir-Riahi : Professeur de recherche à l'Université du Québec à Trois-Rivières (UQTR), Canada. Il a été admis au Cercle d'excellence de l'Université du Québec en 2017. Il a publié 340 articles dans des revues internationales, 6 livres et 15 chapitres de livres. Intérêt de recherche : interactions des médicaments avec l'ADN, l'ARN et les protéines ; délivrance de médicaments.