Dan Luo / W. Mark Saltzman (Hgg.)

Synthetic DNA Delivery Systems

Herausgegeben:Luo, Dan; Saltzman, W. Mark

• Gebundenes Buch

Produktbeschreibung

DNA delivery into cells is a rapidly developing area in gene therapy and biotechnology. Moreover, it is a powerful research tool to determine gene structure, regulation, and function.

Viral methods of DNA delivery are well-characterized and efficient, but little is known about the toxicity and immunogenecity of viral vectors. As a result, non-viral, transfection methods of DNA delivery are of increasing interest.

Synthetic DNA Delivery Systems is a comprehensive and current resource on DNA transfection. The use of histidine-rich peptides and polypeptides as DNA delivery systems and self-assembled delivery systems based on cationic lipids and polymers are discussed. Targeted delivery to organelles, tumor cells and dendritic cells comprise an important topic.

Produktdetails

• Biotechnology Intelligence Unit 7
• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-0-306-47701-0
• 2003
• Seitenzahl: 152
• Erscheinungstermin: 30. September 2003
• Englisch
• Abmessung: 241mm x 160mm x 13mm
• Gewicht: 395g
• ISBN-13: 9780306477010
• ISBN-10: 0306477017
• Artikelnr.: 21300694

Inhaltsangabe

I: Introduction; D. Luo, W.M. Saltzman.
II: Overcoming Cellular Barriers along the DNA Delivery Pathway. Outside of
the cell: Supramolar assemblies of DNA delivery systems; Pitard. At the
cell surface: Engineering the surface properties of synthetic gene delivery
systems; Schaffer. Inside of the cell: Histidine containing peptides and
polypeptides as nucleic acid vectors; Midoux. Intracellular targets for DNA
delivery: nuclei and mitochondria; Torchilin.
III: Targeted DNA Delivery. Immune cells: Mannose receptor-mediated gene
delivery into antigen presenting dendritic cells; Zenke. Muscle:
Electro-gene-transfer: a new approach for muscle gene delivery; Toniatti.
Tumor: Tumor-targeted gene transfer with DNA polyplexes; Wagner.
IV: Novel DNA Delivery Systems. Light: Photochemical transfection: a
technology for efficient light directed gene delivery; Hogset. Ultrasound:
Sonoportation: mechanical DNA delivery by ultrasonic cavitation; Miller,
Greenleaf.