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HIV / AIDS epidemic (diseases that affects a greater no of people worldwide proportions) are a significant threat to humanity and to the growth of nation, the quest for effective anti-HIV drugs remains a fact. Considerable progress has been made in recent years in the field of anti-HIV drug development. A large number of structurally different Coumarins have been found to demonstrate potent anti-HIV activity. The current research article demonstrates the variety of synthetic Coumarins with a specific mechanism of action that corresponds to the various steps of HIV replication.