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The present work was aimed to design and Synthesize benzimidazole derivatives having antibacterial activity using QSAR technique of indirect designing. The indirect drug design approach has been decided to be used because defined three dimensional coordinates for the receptor site of antibacterial benzimidazole was not available. QSAR is capable of determining appropriate distribution of chemical groups around the nucleus, which are necessary to provide desired biological activity.The aim of present study is to design and synthesis of some potent antibacterial benzimidazole derivatives. Their structure confirmation and evaluation of biological activities. Based on the QSAR studies a few new benzimidazole derivatives were synthesized and virtual screening of this synthesized compound was performed.