Synthesis of Few Potential Non-Steroidal Anti-Inflammatory Agents - Debnath, Biplab;Sarma, Prasanta Kumar;Mandal, Sudip Kumar
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Non-steroidal anti-inflammatory drugs are one of the commonly prescribed groups of drugs worldwide and are highly effective as analgesic, antipyretic and anti-inflammatory agents. However, their use is also associated with adverse events such as gastro duodenal ulceration and gastro intestinal bleeding. There is always a great need to develop COX-2 specific inhibitors to avoid the side effects. The present report contains a brief introduction to inflammation, biosynthesis of prostaglandins with emphasis on the enzymes COX-1 and COX-2. The main focus is on the literature survey of indan…mehr

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Produktbeschreibung
Non-steroidal anti-inflammatory drugs are one of the commonly prescribed groups of drugs worldwide and are highly effective as analgesic, antipyretic and anti-inflammatory agents. However, their use is also associated with adverse events such as gastro duodenal ulceration and gastro intestinal bleeding. There is always a great need to develop COX-2 specific inhibitors to avoid the side effects. The present report contains a brief introduction to inflammation, biosynthesis of prostaglandins with emphasis on the enzymes COX-1 and COX-2. The main focus is on the literature survey of indan derivatives and experimental work carried out in the laboratory in an attempt to develop newer and less ulcerogenic NSAIDs.
Autorenporträt
Biplab Debnath est professeur adjoint. BCRCP, Durgapur, West bengal, Inde. Sourabh Kosey est professeur adjoint (pratique de la pharmacie) à l'ISFCP, Punjab, Moga. Mme Ravneet Kaur est étudiante en Pharm.D. Ils ont participé à plusieurs conférences. Ils ont à leur actif plusieurs publications de recherche réputées ainsi que des publications de livres.