SYNTHESIS CHARACTERIZATION AND PHARMACOLOGICAL EVAULATION - Aruna, Dr K.;Lahari, S;Begum, Dr T.Noorjahan
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Novel Phenyl acrylate derivatives (AN1-AN6) were synthesized, characterized by the spectral analysis and screened for Anti-cancer activity by MTT Assay method and Anti-inflammatory activity by Bovin serum albumin method and. The synthetic route involves the equimolar mixture of 2- Acetoxy benzoic acid, Benzaldehyde was dissolved in 25ml of Ethanol to give 2- (chloro carboxy) phenyl acrylate.Various aromatic anilines were added to the 2- [(- 4- chlorophenyl) carbomoyl] phenyl 3- phenyl acrylate dissolved in ethanol. The reaction mixture was stirred and then refluxed for 1hrs and filter the…mehr

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Produktbeschreibung
Novel Phenyl acrylate derivatives (AN1-AN6) were synthesized, characterized by the spectral analysis and screened for Anti-cancer activity by MTT Assay method and Anti-inflammatory activity by Bovin serum albumin method and. The synthetic route involves the equimolar mixture of 2- Acetoxy benzoic acid, Benzaldehyde was dissolved in 25ml of Ethanol to give 2- (chloro carboxy) phenyl acrylate.Various aromatic anilines were added to the 2- [(- 4- chlorophenyl) carbomoyl] phenyl 3- phenyl acrylate dissolved in ethanol. The reaction mixture was stirred and then refluxed for 1hrs and filter the solution to give 6 novel quinoxaline derivatives (AN1-AN6). The compounds show the mild to moderate anti- cancer activity when compared with standard Bevacizumab. Selected derivatives (AN4, AN5, & AN6) were screened for anti-cancer activity. Results revealed that selected derivatives have not shown anti-inflammatory activity.
Autorenporträt
Dr K.Aruna is working as Assistant Professor and in charge HOD of chemistry, JNTUACEA, JNTUA. She has completed her Ph.D in the area of Nanobiotechnolgy with specialization in biosensors from JNTU Hyderabad and M.Tech in Biotechnology from JNTU Hyderabad. She Worked as visiting scientist at NIAB and IIT Hyderabad.