Prof. Dr. S. M. Abe Kawsar

SYNTHESIS AND MICROBIAL SCREENING OF SOME GLUCOPYRANOSIDE DERIVATIVES

Approach to Pharmaceutical Uses

• Broschiertes Buch

Produktbeschreibung

Methyl _-D-glucopyranoside was easily prepared by the treatment of D-glucose with anhydrous methyl alcohol in the presence of hydrogen chloride at freezing temperature. Then N-acetylsulfanilylation of methyl _-D-glucopyranoside has been carried out by the direct method and afforded the 6-O-N-acetylsulfanilyl derivative in an excellent yield. In order to obtain newer products, the 6-O-N-acetylsulfanilyl derivative was further transformed into a series of 2,3,4-tri-O-acyl derivatives containing a wide variety of functionalities in a single molecular framework. The chemical structures of the newly synthesized compounds were elucidated by FTIR, Proton nuclear magnetic resonance spectroscopy, elemental and physicochemical properties analysis. All the newly synthesized D-glucose derivatives were tested for their in vitro antibacterial activity against some human pathogenic bacterial strains. The study revealed that a good number of compounds exhibited promising antibacterial activities. It is expected that the acylated derivatives of D-glucose may be considered as a potential source for developing new and better antibacterial agents against a number of pathogenic organisms.

Produktdetails

• Verlag: Scholar's Press
• Seitenzahl: 132
• Erscheinungstermin: 12. August 2020
• Englisch
• Abmessung: 220mm x 150mm x 8mm
• Gewicht: 215g
• ISBN-13: 9786138938125
• ISBN-10: 6138938127
• Artikelnr.: 60337020

Autorenporträt

Professor Dr. S. M. Abe Kawsar was appointed as a Lecturer in the Department of Chemistry, University of Chittagong, Bangladesh since 2001. Currently, Prof. Kawsar is working as a full Professor (Permanent position) in the Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Department of Chemistry, University of Chittagong, Bangladesh.