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Synthesis of novel substituted [1, 2, 4] triazole have been reported to posses wide spectrum of activities ranging from anti-bacterials, anti-inflammatory, anti- convulsant, antineoplastic, antimalarial, anti-viral, anti-cancer, anti-TB and anti- proliferative. Pyridine, a heterocyclic nucleus played a vital role in the development of different medicinal agents and in the field of agrochemicals. This nucleus is present in many products such as drugs, vitamins, food, flavorings, plant dyes, adhesives and herbicides. It is seen from the current literature that pyridine congeners are associated with different biological properties like pesticidal, insecticides and fungicidal activity. These reports encouraged us to plan for modification of 1,2,4-triazole into various bioactive structures and their subsequent evaluation for antimicrobial, anti-cancer activities.