Asrat Dawit, Yamrot Kinfu, Asfaw Debella

Sub-chronic toxicity study

of the crude methanolic fruit extract of Embelia Schimperi Vatke on some blood parameters, livers and kidney of mice

• Broschiertes Buch

Produktbeschreibung

Embelia schimperi is widely used in traditional medicine in many countries including Ethiopia. There are several reports about the pharmacological properties of Embelia schimperi such as ethno-antihelminthics, anti-bacterials and other activities. However, there are no published reports about the possible toxicological effects of this plant. The present study was designed to evaluate the acute and the sub-chronic toxicity of Embelia schimperi fruit crude methanolic extract. The toxicity study of the plant was carried out on adult Swiss albino mice and the study included gross observation and measurements of changes in body weight, hematological parameters , biochemical parameters and histopathology of liver and kidney of both experimental and control groups of mice. The mice were divided into three groups (12animals/dose) and were administered different doses (400 and 1200mg/kgbwt) of the plant extract orally for eight consecutive weeks. The control group of animals received 2% Dimethyl sulfoxide (DMSO). The body weight of all animals in each group was measured in the beginning and in the end of the experimental period.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 68
• Erscheinungstermin: 9. Juli 2012
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 119g
• ISBN-13: 9783848441488
• ISBN-10: 3848441489
• Artikelnr.: 36085526

Autorenporträt

Asrat Dawit,Msc: Studied Human Anatomy at Medical Faculty of Addis Ababa University.Lecturer in the department of Biomedical Sciences,college of Public Health and Medical sciences of Arbaminch University,Ethiopia.